| 王 猛,王贵玉.从胃肠间质瘤治疗模式转变看肿瘤精准治疗的未来[J].肿瘤学杂志,2021,27(6):434-437. |
| 从胃肠间质瘤治疗模式转变看肿瘤精准治疗的未来 |
| Transformation of Therapeutic Modalities for Gastrointestinal Stromal Tumor：Perspective of Precision Tumor Therapy |
| 投稿时间：2021-05-22 |
| DOI：10.11735/j.issn.1671-170X.2021.06.B004 |
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| 中文关键词: 胃肠间质瘤 外科学 治疗模式 酪氨酸酶抑制剂 耐药 |
| 英文关键词:gastrointestinal stromal tumor surgery therapeutic model tyrosine kinase inhibitor drug resistance |
| 基金项目:国家自然科学基金青年科学基金项目(82002506)；中国博士后科学基金（2019M661301）；哈医大二院中青年创新科学研究基金（KYCX2019?鄄01）；黑龙江省应用技术研究与开发计划项目（GA19C003） |
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| 中文摘要: |
| 摘 要：胃肠间质瘤（gastrointestinal stromal tumor，GIST）治疗方式经历巨大转变，手术不再是唯一的治疗方式。靶向药物酪氨酸酶抑制剂（tyrosine kinase inhibitor，TKI）的出现，使GIST治疗进入靶向时代。以伊马替尼为代表的TKI已成为晚期GIST治疗的基石。新型TKI丰富了治疗的选择，改善了晚期四线治疗无药可用的尴尬局面。随着研究的深入，对c?鄄kit/PDGFRA及其他基因相关通路的探索，对GIST致病基因及突变位点的认识不断丰富，推动着新的靶向药物不断涌现。根据患者基因检测结果，选择最有效的靶向药物，优化最佳药物治疗剂量，从而实现个体化、差异化的分子靶向治疗将成为未来的治疗趋势。 |
| 英文摘要: |
| Abstract：The therapeutic modalities of gastrointestinal stromal tumor(GIST) have be changed constantly and surgery is no longer the only treatment choice. The introduction of imatinib，a tyrosine kinase inhibitor(TKI) targeting the KIT and PDGFRA proteins，revolutionizes medical management of unresectable advanced and metastatic GIST and leads to target therapy era. The new emerging TKIs have enriched treatment options and improved the embarrassing situation of no available fourth-line drugs. Studies have shown that GISTs respond differentially to imatinib due to the variety of mutant status，which prompted the search for target genes and alternative therapies. The explorations of c-kit/PDGFRA and other gene-related pathways have enriched the knowledge of GIST pathogenic genes and mutation sites，promoting development of new targeted drugs. Advancements in next generation sequencing have ushered in a new era of precision oncology. Optimizing the treatment dosage and developing the personalization of therapeutic regimens on the basis of patients’ genomic profiles will become a new trend of cancer therapy in the future. |
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