张信华,李 勇.有关胃肠间质瘤治疗几个争议问题的思考[J].肿瘤学杂志,2021,27(6):429-433.
有关胃肠间质瘤治疗几个争议问题的思考
Certain Controversial Issues in the Treatment of Gastrointestinal Stromal Tumor
投稿时间:2021-06-03  
DOI:10.11735/j.issn.1671-170X.2021.06.B003
中文关键词:  胃肠间质瘤  外科治疗  靶向治疗
英文关键词:gastrointestinal stromal tumor  surgery  targeted therapy
基金项目:
作者单位
张信华 中山大学附属第一医院 
李 勇 河北医科大学第四医院 
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中文摘要:
      摘 要:胃肠间质瘤(gastrointestinal stromal tumor,GIST)的主要治疗方式是外科治疗和靶向治疗。近年靶向新药有突破性进展,但手术治疗仍然是局限期GIST的唯一治愈手段。全文结合文献,就贲门部位GIST的外科治疗、KIT外显子9突变GIST辅助治疗以及复发转移性GIST基因分型和分线治疗的争议问题进行了回顾和探讨,期待更多相关研究和临床证据以解决类似临床决策难题。
英文摘要:
      Abstract:Gastrointestinal stromal tumor (GIST) is mainly treated by surgery and targeted therapy. In recent years,targeted new drugs have emerged and make a breakthrough,but surgery is still the only curative method for primary limited GISTs. In this paper,the controversial issues of surgical treatment of cardiac GIST,adjuvant therapy of those of KIT exon 9 mutation and sequential targeted therapies due to standard lines comparing with to different mutational status in recurrent and/or metastatic GISTs were reviewed and discussed. We look forward to see more relevant research and clinical evidence to solve similar clinical decision-making problems.
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