| 张信华,李 勇.有关胃肠间质瘤治疗几个争议问题的思考[J].肿瘤学杂志,2021,27(6):429-433. |
| 有关胃肠间质瘤治疗几个争议问题的思考 |
| Certain Controversial Issues in the Treatment of Gastrointestinal Stromal Tumor |
| 投稿时间：2021-06-03 |
| DOI：10.11735/j.issn.1671-170X.2021.06.B003 |
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| 中文关键词: 胃肠间质瘤 外科治疗 靶向治疗 |
| 英文关键词:gastrointestinal stromal tumor surgery targeted therapy |
| 基金项目: |
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| 中文摘要: |
| 摘 要：胃肠间质瘤（gastrointestinal stromal tumor，GIST）的主要治疗方式是外科治疗和靶向治疗。近年靶向新药有突破性进展，但手术治疗仍然是局限期GIST的唯一治愈手段。全文结合文献，就贲门部位GIST的外科治疗、KIT外显子9突变GIST辅助治疗以及复发转移性GIST基因分型和分线治疗的争议问题进行了回顾和探讨，期待更多相关研究和临床证据以解决类似临床决策难题。 |
| 英文摘要: |
| Abstract：Gastrointestinal stromal tumor (GIST) is mainly treated by surgery and targeted therapy. In recent years，targeted new drugs have emerged and make a breakthrough，but surgery is still the only curative method for primary limited GISTs. In this paper，the controversial issues of surgical treatment of cardiac GIST，adjuvant therapy of those of KIT exon 9 mutation and sequential targeted therapies due to standard lines comparing with to different mutational status in recurrent and/or metastatic GISTs were reviewed and discussed. We look forward to see more relevant research and clinical evidence to solve similar clinical decision-making problems. |
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