| 姜志平,李风艳.单核细胞趋化蛋白-1及其受体与肿瘤侵袭转移的研究进展[J].肿瘤学杂志,2021,27(5):353-358. |
| 单核细胞趋化蛋白-1及其受体与肿瘤侵袭转移的研究进展 |
| Research Progress on Monocyte Chemoattractant Protein-1 and Its Receptors in Tumor Invasion and Metastasis |
| 投稿时间：2020-09-15 |
| DOI：10.11735/j.issn.1671-170X.2021.05.B005 |
|
 |
| 中文关键词: 单核细胞趋化蛋白-1 CCR2 肿瘤 侵袭 转移 |
| 英文关键词:monocyte chemoattractant protein-1 CCR2 tumor invasion metastasis |
| 基金项目: |
|
| 摘要点击次数: 692 |
| 全文下载次数: 185 |
| 中文摘要: |
| 摘 要：趋化因子已被证实是肿瘤微环境中的核心调节因子，可募集多种免疫细胞至肿瘤微环境。趋化因子通过在多种类型癌细胞增殖、迁移、侵袭和血管生成中的作用而促进恶性肿瘤的进展。单核细胞趋化蛋白-1（monocyte chemoattractant protein-1，MCP-1/CCL2）是CC类趋化因子家族成员之一。CCL2可与其受体（以CC趋化因子受体2，CCR2为主）结合，通过多种信号传导通路促进恶性肿瘤的侵袭转移。深入研究CCL2/CCR2在恶性肿瘤中的作用机制，可能对恶性肿瘤的靶向治疗具有重大意义。全文就近年来研究较多的乳腺癌、前列腺癌、卵巢癌、结直肠癌等恶性肿瘤侵袭转移中CCL2/CCR2的作用机制进行综述。 |
| 英文摘要: |
| Abstract：Chemokines have been proven to be core regulators in the tumor microenvironment to recruit a variety of immune cells. Chemokines promote the progression of malignant tumors through enhancing proliferation，migration，invasion and angiogenesis of various types of cancer cells. Monocyte chemoattractant protein-1(MCP-1/CCL2) is a member of the CC chemokine family. CCL2 binds to its receptor CC chemokine receptor 2(CCR2) and promotes the invasion and metastasis of malignant tumors via a variety of signal transduction pathways. In-depth study of the mechanism of CCL2/CCR2 in malignant tumors may contribute to the development of targeted cancer therapy. This article reviews the recent progress on the mechanism of CCL2/CCR2 in invasion and metastasis of breast cancer，prostate cancer，ovarian cancer，colorectal cancer and other malignant tumors. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |