| 王 以,张睿鹏,袁 莉.口腔微生物与胃癌发生发展相关性的研究进展[J].肿瘤学杂志,2021,27(4):244-248. |
| 口腔微生物与胃癌发生发展相关性的研究进展 |
| Research Progress on Relationship between Oral Microbiomes and Occurrence and Development of Gastric Cancer |
| 投稿时间：2020-11-17 |
| DOI：10.11735/j.issn.1671-170X.2021.04.B002 |
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| 中文关键词: 胃肿瘤 口腔微生物 韦荣球菌属 梭杆菌属 链球菌属 |
| 英文关键词:gastric cancer oral microbiomes veillonella fusobacterium streptococcus |
| 基金项目:国家自然科学基金面上项目（82074245）；浙江省自然科学基金面上项目（LY18H290006）；浙江省中医药重大研究项目（2018ZY006）；浙江省中医药科技计划重点研究项目（2019ZZ010） |
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| 中文摘要: |
| 摘 要：胃癌作为一种发病率高且预后不佳的上消化道恶性肿瘤，其发病机制错综复杂。随着16S rRNA测序及宏基因组测序等技术的发展，越来越多的研究发现了口腔微生物与胃癌的发生发展具有联系。口腔微生物可通过过度炎症反应、促进癌细胞抗凋亡和产生致癌物质途径促进癌症的发生发展。明确口腔微生物如韦荣球菌属、梭杆菌属、链球菌属等与胃癌的关系可以为探究胃癌的发病机制及多学科联合治疗胃癌提供帮助。全文就口腔微生物与胃癌相关性的研究现状进行综述。 |
| 英文摘要: |
| Abstract：As an upper gastrointestinal tumor with a high incidence and poor prognosis，gastric cancer has a complicated pathogenesis. With the development of 16S rRNA sequencing and metagenomic sequencing，more and more studies have found that oral microbiomes are related to the occurrence and development of gastric cancer. Oral microbiomes can promote the occurrence and development of cancer through excessive inflammation，promote cancer cells to suppress apoptosis and produce carcinogens. The clarification of the relationship between oral microbiomes(such as Veillonella，Fusobacterium，Streptococcus) and gastric cancer would be helpful for understanding the pathogenesis of gastric cancer and multidisciplinary treatment of gastric cancer. This article reviews the research progress of relationship between oral microbiomes and gastric cancer. |
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