| 吴茂芳,蔡静静,莫 欣.多发肺结节的鉴别策略研究进展[J].肿瘤学杂志,2021,27(3):170-174. |
| 多发肺结节的鉴别策略研究进展 |
| Research Progress on Differential Strategies of Multiple Lung Nodules |
| 投稿时间：2020-08-06 |
| DOI：10.11735/j.issn.1671-170X.2021.03.B003 |
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| 中文关键词: 肺癌 多发肺结节 肺内转移 鉴别诊断 |
| 英文关键词:lung cancer multiple lung nodules intrapulmonary metastatic differential diagnosis |
| 基金项目:国家自然科学基金资助项目（81860513） |
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| 摘要点击次数: 887 |
| 全文下载次数: 190 |
| 中文摘要: |
| 摘 要：肺癌多结节病灶的检出日益增加，准确鉴别多结节病灶是多原发肺癌（multiple primary lung cancer，MPLC）或肺内转移（intrapulmonary metastasis，IPM）对患者治疗方案的选择及预后至关重要。在临床工作中，经典的鉴别方法主要依靠形态组织学表现，对组织学类型相似或缺乏转移特征的患者，诊断仍存在较大困难。分子生物和基因学技术的兴起，为同时性多结节病灶的性质判断提供更客观全面的信息。全文主要从临床影像学特点、组织形态学差异和分子遗传学研究等方面对肺癌多发结节的鉴别诊断策略进行综述。 |
| 英文摘要: |
| Abstract：The incidence of lung carcinoma patients presenting with multiple nodules has been increasing. Differentiation between multiple primary tumors and intrapulmonary metastases in patients with multiple lung nodules will help to predict disease outcome and guide treatment，but it can be a challenge. Classically，the differentiation relies on histopathological features of the lesion. However，the development of molecular biology and genomics technology provides objective and comprehensive information for such differentiation. This article reviews the differential diagnosis strategies for multiple lung cancer nodules from the imaging characteristics，histopathological features and molecular genetic markers. |
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