| 许世莹,黄煜庆,郑国湾.VSIG4在恶性肿瘤诊治中的研究进展[J].肿瘤学杂志,2021,27(2):148-152. |
| VSIG4在恶性肿瘤诊治中的研究进展 |
| Research Progress of VSIG4 in Diagnosis and Treatment of Malignant Tumors |
| 投稿时间：2020-08-26 |
| DOI：10.11735/j.issn.1671-170X.2021.02.B011 |
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| 中文关键词: VSIG4 新型B7相关免疫球蛋白 恶性肿瘤 治疗靶点 |
| 英文关键词:VSIG4 novel B7 family-related immune globulin malignant tumor therapeutic target |
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| 中文摘要: |
| 摘 要：VSIG4（the protein V-set and immune globulin domain-containing 4）是一种与巨噬细胞蛋白质相关的新的B7相关免疫球蛋白的Ⅰ型跨膜蛋白，具有抑制T细胞活化的能力，也被称为CRIg（免疫球蛋白超家族）和Z39Ig，在病原体识别和清除中起关键作用。恶性肿瘤中，VSIG4的表达及VSIG4阳性T细胞的增加可能预示更高的侵袭性和复发风险。全文就VSIG4与各肿瘤间的关系作一简要概述，为VSIG4与恶性肿瘤诊治提供参考。 |
| 英文摘要: |
| Abstract：The protein V-set and immunoglobulin domain containing protein 4(VSIG4)，also known as CRIg and Z39Ig，is a novel type Ⅰ transmembrane protein of B7-related immunoglobulin superfamily and a negative regulator of T cell activation，which plays a key role in pathogen identification and clearance. In malignant tumors，the expression of VSIG4 and the increase of VSIG4 positive T cells may indicate higher aggressiveness and greater risk of recurrence. This article gives a brief overview of the relationship between VSIG4 and various cancer，and provides references for application of VSIG4 in the diagnosis and treatment of malignant tumors. |
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