| 冯 柳,蒋春灵,李道靖.益生菌对头颈部肿瘤患者放化疗引起的口腔黏膜炎的作用分析[J].肿瘤学杂志,2021,27(2):136-141. |
| 益生菌对头颈部肿瘤患者放化疗引起的口腔黏膜炎的作用分析 |
| Efficacy of Probiotics for Radiotherapy/Chemotherapy-induced Oral Mucositis in Patients with Head and Neck Cancer |
| 投稿时间：2019-12-21 |
| DOI：10.11735/j.issn.1671-170X.2021.02.B009 |
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| 中文关键词: 益生菌 头颈部肿瘤 口腔黏膜炎 放化疗 |
| 英文关键词:probiotics head and neck cancer oral mucositis radio-chemotherapy |
| 基金项目:北京医卫健康公益基金会项目（YWJKJJHKYJJ-B17335） |
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| 中文摘要: |
| 摘 要：［目的］探讨联合应用益生菌对头颈部肿瘤放化疗患者放射性口腔黏膜炎的治疗作用。［方法］ 51例头颈部肿瘤患者纳入研究，随机分为放疗+化疗+安慰剂即对照组(RCP)和放疗+化疗+益生菌联合即实验组(RCPC)两组。对患者口腔黏膜炎的发生、肿瘤反应、免疫功能、肠道微生物群多样性等进行监测分析。［结果］ RCPC组患者口腔黏膜炎发生率显著降低（88.5% vs 100%，P=0.037），而肿瘤反应与RCP组相当（100% vs 100%，P=0.583）。 RCPC组淋巴细胞比例、CD4+T细胞、CD3+T细胞数量均增加(P均<0.05)。高通量测序结果表明，益生菌的摄入显著增加了拟杆菌、志贺氏菌、对映体的种群数量，同时降低了肠道菌群中普雷沃氏菌和链状杆菌的丰度。［结论］ 益生菌联合治疗可通过改变肠道菌群，提高头颈部肿瘤患者的免疫反应，降低口腔黏膜炎的发生率。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the efficacy of probiotic combination for chemotherapy/radiotherapy-induced oral mucositis in patients with head and neck cancer. ［Methods］ Fifty one patients with head and neck cancer were enrolled and randomly divided into two groups：radiotherapy+chemotherapy+placebo(RCP) and radiotherapy+chemotherapy+ probiotic combination(RCPC). The occurrence of oral mucositis，tumor response，immune function and intestinal microbial diversity were monitored and analyzed. ［Results］ The incidence of oral mucositis in the RCPC group was significantly lower than that in the RCPC group(88.5% vs 100%，P=0.037)，while the tumor response was similar to that in the RCP group(100% vs 100%，P=0.583). The proportion of lymphocytes，the number of CD4+ T cells and CD3+ T cells in RCPC group were increased(all P<0.05). High throughput sequencing results showed that probiotics intake significantly increased the number of Bacteroides，Escherichia-Shigella and Parabacterodies，and decreased the abundance of Prevotella and Catenibacterium in intestinal flora.［Conclusion］ Probiotics combination therapy can improve the immune response and reduce the incidence of oral mucositis by changing intestinal flora in patients with head and neck cancer receiving concurrent radio-chemotherapy. |
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