| 孙路遥,尹梦媛,谢克平.肿瘤相关成纤维细胞在胰腺癌发生发展中的研究进展[J].肿瘤学杂志,2021,27(2):95-104. |
| 肿瘤相关成纤维细胞在胰腺癌发生发展中的研究进展 |
| Research Progress on Cancer-associated Fibroblasts in Pancreatic Cancer Development |
| 投稿时间：2020-07-02 |
| DOI：10.11735/j.issn.1671-170X.2021.02.B003 |
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| 中文关键词: 胰腺肿瘤 肿瘤相关性成纤维细胞 肿瘤微环境 异质性 类器官 |
| 英文关键词:pancreatic cancer cancer-associated fibroblasts tumor microenvironment heterogeneity organoid |
| 基金项目:国家自然科学基金（81672572）；中央高校基本科研项目（2019PY25） |
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| 中文摘要: |
| 摘 要：胰腺癌是致命的恶性肿瘤之一，由于缺乏早期、敏感及特异性的诊断标志物，大多数患者确诊时已处于晚期。胰腺癌又称硬癌，其肿瘤组织中含有大量的间质成分，广泛的纤维化是胰腺癌的重要特征。肿瘤相关成纤维细胞（cancer-associated fibroblasts，CAFs）是肿瘤微环境中重要的组成成分，研究表明CAFs参与胰腺癌细胞增殖、迁移、侵袭、耐药等生物学过程。全文主要介绍胰腺癌中CAFs的异质性及其在胰腺癌发生发展中的作用，并阐述了类器官培养技术在CAFs研究中的应用，以及靶向CAFs进行肿瘤治疗的进展。 |
| 英文摘要: |
| Abstract：Pancreatic cancer is one of the most devastating malignant tumors；due to lack of early，sensitive and specific diagnostic markers，most patients with pancreatic cancer are in the advanced stage when they are diagnosed. Pancreatic cancer is also known as hard cancer，containing a large amount of interstitial components，and the extensive fibrosis is an important feature of pancreatic cancer. Cancer-associated fibroblasts(CAFs) are an important component of the tumor microenvironment. A large number of studies have shown that CAFs regulate the development of pancreatic cancer，including cell proliferation，migration，invasion，and drug resistance. This review mainly introduces the heterogeneity of CAFs and its role in the occurrence and development of pancreatic cancer，describes the organoid culture technique in the study of CAFs，and summarizes the progress of targeting CAFs for tumor treatment. |
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