| 李 静,李青原,魏 鑫.初诊初治肺癌患者20例呼吸特征标志物研究[J].肿瘤学杂志,2021,27(1):42-46. |
| 初诊初治肺癌患者20例呼吸特征标志物研究 |
| Study on Tumor Markers in Exhaled Air of 20 Patients with Lung Cancer |
| 投稿时间：2020-03-05 |
| DOI：10.11735/j.issn.1671-170X.2021.01.B009 |
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| 中文关键词: 肺肿瘤 初诊初治 呼吸分析 挥发性化合物 气相色谱—质谱法 |
| 英文关键词:lung cancer primary diagnosis and treatment breath analysis volatile compounds gas chromatography-mass spectrometry |
| 基金项目:国家自然科学基金面上项目（81471701）；中国医学科学院医学与健康科技创新工程项目（2018-I2M-AI-012） |
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| 中文摘要: |
| 摘 要：［目的］ 对排除自身影响因素条件下（饮食、药物和吸烟）肺癌患者呼吸标志物进行了研究，探讨呼出气中特征性挥发性化合物对肺癌无创诊断的价值。［方法］ 本实验通过气相色谱—质谱联用仪对20例初诊初治肺癌患者和11例健康志愿者空腹状态时呼出气体中挥发性化合物进行定性定量分析。［结果］ 通过曼-惠特尼U检验对肺癌患者以及健康对照组的成分均值比较，筛选出二硫化碳（对照组24.21±19.94ppb，肺癌组1.28±3.95ppb）、正己烷（对照组16.75±16.93ppb，肺癌组0.46±1.18ppb） 和乙苯（对照组6.30±2.27ppb，肺癌组1.46±2.12ppb）。3种挥发性化合物浓度差异具有统计意义（P值均<0.05）。二硫化碳、正己烷和乙苯三种物质联合指标的受试者工作特征曲线曲线下的面积为0.932，敏感度为95%，特异性为90.9%，P<0.01。［结论］ 本研究初步探讨了在排除自身影响因素条件下（饮食、药物和吸烟）的肺癌呼吸特征标志物，为肺癌呼吸标志物研究的进一步发展提供了参考依据。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the value of volatile compounds in exhaled air of patients with lung cancer in the non-invasive diagnosis. ［Methods］ The volatile compounds in the exhaled air of 20 newly diagnosed patients with lung cancer and 11 healthy volunteers in the fasting state were qualitatively and quantitatively analyzed by gas chromatography-mass spectrometry(GC-MS). ［Results］ There were significant differences in the concentrations of three volatile compounds of carbon disulfide，hexane and ethylbenzene between healthy control group and lung cancer patients as shown by Mann-Whitney U test(carbon disulfide：24.21±19.94ppb vs 1.28±3.95ppb，hexane：16.75±16.93ppb vs 0.46±1.18ppb，ethylbenzene：6.30±2.27ppb vs 46±2.12ppb；all P<0.05). The area under the receiver operating characteristic curve(AUC) of the combination of three volatile compounds for diagnosis of lung cancer was 0.932，the sensitivity was 95% and the specificity was 90.9%(P<0.01). ［Conclusion］ This study preliminarily explored the lung cancer breath markers under the condition of excluding their own influencing factors(diet，medicine and smoking)，to provide a reference for the further development of lung cancer breath markers research. |
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