| 刘帅臣,李玉明.肿瘤相关长链非编码RNA FEZF1-AS1的调控作用研究进展[J].肿瘤学杂志,2020,26(12):1075-1079. |
| 肿瘤相关长链非编码RNA FEZF1-AS1的调控作用研究进展 |
| Research Progress on Regulating Role of Cancer-related Long Non-coding RNA FEZF1-AS1 |
| 投稿时间：2019-12-13 |
| DOI：10.11735/j.issn.1671-170X.2020.12.B013 |
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| 中文关键词: 肿瘤 长链非编码RNAs FEZF1-AS1rs long non-coding RNA FEZF1-AS1 |
| 英文关键词:cancers long non-coding RNA FEZF1-AS1 |
| 基金项目:山东省自然科学基金面上项目（ZR2019MH080） |
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| 中文摘要: |
| 摘 要：长链非编码RNAs（1ong non-coding RNAs，lncRNAs）已被证实是人类癌症相关的重要调节因子，对肿瘤的增殖、侵袭、耐药等病理生理过程具有重要意义。FEZ家族锌指1反义RNA 1（FEZ family zinc finger 1 antisense RNA 1，FEZF1-AS1）作为lncRNAs家族中的重要成员之一，在多种肿瘤中异常表达，通过多种方式发挥其独特的功能及生物学作用，在未来有望成为新兴肿瘤诊断、预后标志物及治疗新靶点。全文就FEZF1-AS1在消化道肿瘤、鼻咽癌、肺癌、乳腺癌等恶性肿瘤发生发展中的作用作一综述。 |
| 英文摘要: |
| Abstract：Long non-coding RNAs (lncRNAs) have been recognized as important regulators of human cancer，and is of significance for pathological and physiological processes such as tumor proliferation，invasion and drug resistance. FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1)，one of major members of lncRNAs，is abnormally expressed in various cancer，playing its unique and biological role with various ways. FEZF1-AS1 is expected to become a biomarker for tumor diagnosis and prognosis，and novel therapeutic target in the future. This article reviews the role of FEZF1-AS1 in the occurrence and development of digestive cancers，lung cancer，breast cancer，and nasopharyngeal cancer. |
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