| 刘汉卿,陈 创,涂 毅.钠碘同向转运体在分化型甲状腺癌中异常表达的研究进展[J].肿瘤学杂志,2020,26(12):1068-1074. |
| 钠碘同向转运体在分化型甲状腺癌中异常表达的研究进展 |
| Research Progress on Abnormal Expression of the Sodium-Iodide Symporter in Differentiated Thyroid Cancer |
| 投稿时间：2020-02-15 |
| DOI：10.11735/j.issn.1671-170X.2020.12.B012 |
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| 中文关键词: 钠碘同向转运体 BRAF突变 PI3K/AKT1通路变异 RAS突变 PTEN突变 药物靶点 |
| 英文关键词:the sodium-iodide symporter BRAF mutation PI3K/AKT1 pathway mutation RAS mutation PTEN mutation drug target |
| 基金项目:武汉市中青年医学骨干人才计划；武汉大学人民医院重点人才项目 |
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| 中文摘要: |
| 摘 要：放射性核素碘内照射（131I治疗）是分化型甲状腺癌的重要治疗方式，钠碘同向转运体在131I的跨膜转运中起关键作用。而钠碘同向转运体在肿瘤细胞内均有不同程度的表达异常，这与驱动变异密切相关。全文就钠碘同向转运体的分子特征、调节机制及与BRAF突变、PI3K/AKT1通路变异、RAS突变和PTEN突变之间的关系和研究进展作一综述，并总结药物靶点设计与用药方案，为下一步研究提供新的思路。vels |
| 英文摘要: |
| Abstract：Radioiodine internal irritation(131I) is an important treatment for differentiated thyroid cancer and the sodium-iodide symporters play a key role in the transmembrane transport of 131I. The sodium-iodide symporters are abnormally expressed in tumor cells to varying degrees，which is closely related to driver mutations. This article reviews the molecular characteristics，regulatory mechanisms of sodium-iodide symporters，and their relationships with BRAF mutations，PI3K/AKT1 pathway mutations，RAS mutations，and PTEN mutations. The drug target designs and treatment regimens have been summarized to provide insights for future studies. |
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