| 钟山亮,冯继锋.环状RNA与乳腺癌发生、发展和耐药关系的研究进展[J].肿瘤学杂志,2020,26(12):1013-1018. |
| 环状RNA与乳腺癌发生、发展和耐药关系的研究进展 |
| Research Progress on Relationship of Circular RNAs with Development，Progression and Drug?鄄resistance of Breast Cancer |
| 投稿时间：2020-07-13 |
| DOI：10.11735/j.issn.1671-170X.2020.12.B002 |
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| 中文关键词: 环状RNA 乳腺肿瘤 生物标志物 调控作用 |
| 英文关键词:circular RNA breast neoplasms biomarkers regulation |
| 基金项目:国家自然科学基金（81602551）；南京医科大学附属肿瘤医院青蓝项目（QL201810） |
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| 中文摘要: |
| 摘 要：乳腺癌是女性最常见的恶性肿瘤之一，严重威胁女性健康，但对其发生、发展、转移和耐药机制尚不完全明确。环状RNA（circRNA）是一类具有闭合环状结构的内源性RNA分子。随着高通量测序技术的发展，大量circRNAs被发现，并证实其具有转录后调控的功能后，circRNAs已成为肿瘤研究领域的热点。近几年，大量研究报道了circRNAs在肿瘤全过程中的作用。全文就circRNAs在乳腺癌发生、发展、侵袭、转移和耐药中的作用进行综述，为乳腺癌的诊疗提供新思路。 |
| 英文摘要: |
| Abstract：Breast cancer is the most common malignancies in women，however，the underlying mechanisms of occurrence，development，metastasis and drug resistance still remain unclear. Circular RNA(circRNA) is a class of endogenous RNA with a closed loop structure. With the development of high-throughput RNA sequencing techniques，numerous circRNAs have been identified and become a research hotspot in oncology after circRNAs were found to post-transcriptionally regulate gene expression. A number of studies reported the roles of circRNAs in the whole process of tumor development. In this article，we review the roles of circRNAs in development，progression，invasion，metastasis and drug-resistance of breast cancer，which may lead to novel strategies for the diagnosis and therapy of breast cancer. |
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