| 梁培德,曾焕城.乳腺癌腋窝前哨淋巴结探查术的研究进展[J].肿瘤学杂志,2020,26(11):995-1001. |
| 乳腺癌腋窝前哨淋巴结探查术的研究进展 |
| Progress on Axillary Sentinel Lymph Node Biopsy for Breast Cancer |
| 投稿时间：2019-11-21 |
| DOI：10.11735/j.issn.1671-170X.2020.11.B014 |
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| 中文关键词: 乳腺肿物 前哨淋巴结活检术 淋巴结切除术 |
| 英文关键词:breast neoplasms sentinel lymph node biopsy lymph node excision |
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| 中文摘要: |
| 摘 要：前哨淋巴结活检术 (sentinel lymph node biopsy，SLNB)凭着高安全性、高准确性已成为腋窝淋巴结阴性早期患者腋窝处理标准术式。随着对SLNB深入研究，其示踪技术及临床应用也发生变化。荧光成像、超顺磁性氧化铁等有着更高综合性能的新型技术也逐渐应用于临床。SLNB在新辅助化疗患者中应用一直存在争议，其可行性仍需更多研究验证。此外，有学者尝试开发数学模型评估腋窝状态，筛选部分前哨淋巴结阳性患者避免腋窝淋巴结廓清。近年甚至有研究表明SLNB存在过度治疗可能，现有针对该问题的临床研究尚在进行中，探索免去腋窝淋巴结阴性乳腺癌患者腋窝处理的可行性。 |
| 英文摘要: |
| Abstract：Sentinel lymph node biopsy(sentinel lymph node biopsy，SLNB) has been the standard surgical operation for patients suffered in early breast cancer with negative axillary lymph nodes because of high security and accuracy. With the further studies，the tracer technology and clinical application of SLNB are also developing. Fluorescence imaging，superparamagnetic iron oxide and other new technologies with higher comprehensive performance have been gradually applied in clinic. The application of SLNB in patients treated with neoadjuvant chemotherapy has been controversial，and its feasibility still needs to be verified by more studies. In addition，some scholars are trying to develop mathematical models to evaluate axillary status，which is in order to select some patients with positive sentinel nodes to avoid axillary node clearance. Recent studies even found overtreatment may occur with SLNB. As for this particular problem，clinical trials on exploring the feasibility of selecting some breast cancer patients with negative axillary lymph node to avoid axillary treatment are still in process. |
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