| 张顺礼,王雅琪,胡继卫.乳腺癌组织中核仁纺缍体相关蛋白1表达与腋窝淋巴结转移的关系[J].肿瘤学杂志,2020,26(11):957-961. |
| 乳腺癌组织中核仁纺缍体相关蛋白1表达与腋窝淋巴结转移的关系 |
| Relationship Between Expression of Nucleolus Spinosa-related Protein 1 and Axillary Lymph Node Metastasis in Breast Cancer Patients |
| 投稿时间：2020-07-08 |
| DOI：10.11735/j.issn.1671-170X.2020.11.B006 |
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| 中文关键词: 乳腺癌 核仁纺缍体相关蛋白1 淋巴结转移 免疫组织化学染色法 |
| 英文关键词:breast cancer nucleolus spinal body associated protein 1 lymph node metastasis immunohistochemical staining |
| 基金项目:河北省卫生和计划生育委员会科研基金项目（20160874） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺癌组织中核仁纺缍体相关蛋白1（nucleolus spinosa-related protein 1，NuSAP1）的表达与腋窝淋巴结转移的关系。［方法］ 采用免疫组织化学染色法检测100例乳腺癌组织（浸润性导管癌）及其配对的癌旁组织（距离肿瘤边缘＞3cm）中NuSAP1、Hedgehog信号通路相关蛋白（Smo和Gli-1）表达水平。采用Logistic多因素分析影响乳腺癌腋窝淋巴结转移的影响因素。［结果］ 乳腺癌组织中NuSAP1高表达率为65%（65/100），明显高于癌旁组织的18%（18/100）（χ2=45.945，P＜0.001）。NuSAP1高表达组中WHO分级Ⅲ级、TNM Ⅲ期、腋窝淋巴结转移率均高于低表达组（P＜0.05）。WHO分级Ⅲ级（OR=1.689，95%CI：1.240~3.333）、TNM Ⅲ期（OR=1.543，95%CI：1.345~3.602）、三阴性乳腺癌（OR=2.786，95%CI：1.764~4.002）和NuSAP1高表达（OR=2.507，95%CI：1.684~3.971）是乳腺癌患者腋窝淋巴结转移的独立影响因素（P＜0.05）。NuSAP1表达水平与腋窝淋巴结转移数目呈正相关（r=0.561，P＜0.001）。NuSAP1表达与Smo、Gli-1表达水平呈正相关（r分别为0.748和0.528，P均＜0.001）。［结论］ NuSAP1可能通过激活Hedgehog信号通路参与腋窝淋巴结的转移。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the relationship between expression of nucleolus spinosa-related protein 1(NuSAP1) and axillary lymph node metastasis in breast cancer. ［Methods］ Immunohistochemical staining was used to detect the expression levels of NuSAP1，Hedgehog signaling pathway-related proteins(Smo and Gli-1) in 100 breast cancer tissue samples(infiltrating ductal carcinoma) and corresponding adjacent tissue samples(>3 cm from the tumor edge). Multivariate Logistic analysis was used to analyze the risk factors of breast cancer axillary lymph node metastasis. ［Results］ The high expression rate of NuSAP1 in breast cancer tissues was significantly higher than that in adjacent tissues(65% vs 18%，χ2=45.945，P＜0.001). In NuSAP1 high-expression group ，the rates of WHO grade Ⅲ，TNM stage Ⅲ and axillary lymph node metastasis were higher than those in low expression group(P＜0.05). WHO grade Ⅲ(OR=1.689，95%CI：1.240~3.333)，TNM stage Ⅲ(OR=1.543，95%CI：1.345~3.602)，triple negative breast cancer(OR=2.786，95 %CI：1.764~4.002) and high expression of NuSAP1(OR=2.507，95%CI：1.684~3.971) were independent risk factors of axillary lymph node metastasis in breast cancer patients(P<0.05). The expression level of NuSAP1 was positively correlated with the number of metastatic axillary lymph nodes(r=0.561，P<0.001). The expression levels of NuSAP1 were positively correlated with the expression levels of Smo and Gli-1，respectively(r=0.748 and 0.528，P<0.001). ［Conclusion］ NuSAP1 may be involved in the axillary lymph node metastasis by activating the Hedgehog signaling pathway. |
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