| 耿仕涛,卢 昆,张尊月.肠道菌群对肿瘤微环境调节的研究进展[J].肿瘤学杂志,2020,26(11):946-952. |
| 肠道菌群对肿瘤微环境调节的研究进展 |
| Progress on Regulation of Intestinal Flora on Tumor Microenvironment |
| 投稿时间：2019-12-16 |
| DOI：10.11735/j.issn.1671-170X.2020.11.B004 |
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| 中文关键词: 肿瘤微环境 肠道菌群 免疫逃避 |
| 英文关键词:tumor microenvironment intestinal flora immune evasion |
| 基金项目:云南省科技厅科技项目（2018DH006） |
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| 摘要点击次数: 1041 |
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| 中文摘要: |
| 摘 要：肿瘤微环境是肿瘤生长所处的环境，作为肿瘤细胞赖以生存的场所，对肿瘤的演变起着至关重要的作用，肿瘤微环境能调控肿瘤的生长，促进肿瘤侵袭和转移，介导肿瘤的免疫逃避，对肿瘤的发展起着关键性作用。因此，研究肿瘤微环境的调节机制对肿瘤的治疗具有积极意义。肠道菌群与肿瘤的发生发展具有相关性，肠道菌群能够调节肿瘤微环境，促进肿瘤发展。全文综述肿瘤微环境在肿瘤发展中的作用和介导肿瘤免疫逃避的细胞机制和分子机制，简述肠道菌群通过对肿瘤炎性微环境和免疫微环境的调节来影响肿瘤的发展，从而为肿瘤的治疗尤其是免疫治疗开发基于肠道菌群为靶点的新方法提供思路。 |
| 英文摘要: |
| Abstract：Tumor microenvironment(TME) is the environment in which tumors grow. TME can regulate tumor growth，promote tumor invasion and metastasis，mediate tumor immune escape，and play a key role in tumor development. Therefore，it is of significance to study the regulatory mechanism of TME for the treatment of tumors. This review introduces the role of TME in tumor development and the cellular and molecular mechanisms of tumor immune escape；it also briefly describes how intestinal microflora can affect tumor development by regulating tumor inflammatory microenvironment and immune microenvironment，to provide reference for tumor treatment，especially immunotherapy based on intestinal microflora as therapeutic targets. |
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