贾琳琳,陈进宝,吴宏磊.肿瘤相关巨噬细胞与结肠肿瘤微环境关系的研究进展[J].肿瘤学杂志,2020,26(11):941-945.
肿瘤相关巨噬细胞与结肠肿瘤微环境关系的研究进展
Progress on Relationship Between Tumor-associated Macrophages and Microenvironment in Colon Tumor
投稿时间:2020-02-26  
DOI:10.11735/j.issn.1671-170X.2020.11.B003
中文关键词:  肿瘤相关巨噬细胞  结肠癌  肿瘤微环境
英文关键词:tumor-associated macrophages  colon cancer  tumor microenvironment
基金项目:国家自然科学基金面上项目(81873137)
作者单位
贾琳琳 上海中医药大学附属普陀医院 
陈进宝 上海中医药大学附属普陀医院 
吴宏磊 上海中医药大学附属普陀医院 
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中文摘要:
      摘 要:肿瘤微环境(tumor microenvironment,TME)是肿瘤细胞与人体免疫系统相互作用的首要场所,包含肿瘤细胞、免疫细胞、间质细胞及其分泌的活性因子等,深深地影响着肿瘤的产生、发展和转移。巨噬细胞是非常可塑的细胞,TME中的巨噬细胞被称为肿瘤相关巨噬细胞(tumor-associated macrophages,TAMs),在结肠癌发生发展的不同阶段,对TME的刺激能表达不同的功能。近年来TAMs在TME中的作用也得到了更多的关注。因此了解TAMs与结肠癌TME的关系,对深入研究TAMs在结肠肿瘤中的作用具有重要意义。全文对TAMs与结肠癌TME的关系进行综述,以期为深入探究TAMs在结肠癌中的作用提供新的线索。
英文摘要:
      Abstract:Tumor microenvironment(TME) is the primary site of interaction between tumor cells and human immune system. TME contains tumor cells,immune cells,stromal cells and related active factors,which deeply affect the initiation,progression and metastasis of tumors. Macrophages are very plastic cells,the macrophages in TME(TAMs) serve various functions by stimulating TME at different stages of tumor occurrence and development. Understanding the relationship between TAMs and colon cancer microenvironment is of great significance in colon cancer. This article reviews the relationship between TAMs and TME in colon cancer to provide reference for further exploring the role of TAMs in colon cancer and its potential clinical application.
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