黄江标,韦 艳,张志敏.Let-7 miRNA家族:一种潜在的免疫治疗靶点[J].肿瘤学杂志,2020,26(11):929-934. |
Let-7 miRNA家族:一种潜在的免疫治疗靶点 |
Let-7 miRNA Family:A Potential Target for Immunotherapy |
投稿时间:2019-11-20 |
DOI:10.11735/j.issn.1671-170X.2020.11.B001 |
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中文关键词: let-7 miRNA 肿瘤 免疫治疗 |
英文关键词:let-7 miRNA tumor immunotherapy |
基金项目:国家自然科学基金青年项目(81301631);第七批中国博士后科研基金特别资助(2014T70977);湖北省自然科学基金面上项目(2018CFB733);湖北省卫计委青年人才项目(WJ2017H0036);武汉市中青年医学骨干人才培养工程基金资助 |
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中文摘要: |
摘 要:肿瘤免疫治疗是目前肿瘤治疗研究进展的最新热点,寻找新的免疫治疗靶点为未来开发新的有效抗癌药物提供了支持。let-7家族是一种新型 miRNA,可通过参与调节免疫细胞的代谢、成熟及活化过程,调控免疫系统的免疫杀伤效应,被认为可能是一种免疫治疗新的靶点分子。全文综述let-7与免疫系统中的效应细胞之间的相互作用及其机制,为未来寻找新的免疫治疗靶点提供参考。 |
英文摘要: |
Abstract:Immunotherapy is a hot topic in the field of tumor therapy,and to search new targets of immunotherapy will provide support for the development of new effective anticancer drugs in the future. Let-7 family,as one type of miRNAs,can regulate the progress of metabolism,maturation and activation of immune cells,so as to modulate anti-tumor effect of the immune system,which is considered as a new target molecule of immunotherapy. In this paper,we reviewed the interaction between let-7 and effector cells in the immune system and its mechanism,which may provide a reliable reference for finding new targets of immunotherapy in the future. |
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