| 刘雪琴,褚俊峰,王海英.PET-CT定量参数与弥漫大B细胞淋巴瘤患者预后的相关性分析[J].肿瘤学杂志,2020,26(10):897-901. |
| PET-CT定量参数与弥漫大B细胞淋巴瘤患者预后的相关性分析 |
| Correlation of Quantitative PET-CT Parameters with Prognosis of Patients with Diffuse Large B-cell Lymphoma |
| 投稿时间：2019-10-09 |
| DOI：10.11735/j.issn.1671-170X.2020.10.B009 |
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| 中文关键词: 弥漫大B细胞淋巴瘤 最大标准化摄取值 氟脱氧葡萄糖F18 预后 |
| 英文关键词:diffuse large B cell lymphoma maximum standard uptake value fluorodeoxyglucose F18 prognosis |
| 基金项目:国家自然科学基金（81470365） |
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| 摘要点击次数: 1048 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨弥漫大B细胞淋巴瘤（DLBCL）治疗前18F-FDG PET/CT显像中肿瘤SUVmax、SULmax、MTV、TLG与预后的相关性。［方法］回顾性分析诊治的116例DLBCL患者资料，所有患者治疗前行18F-FDG PET/CT显像，均有完整的临床随访数据。分析PET-CT代谢参数与预后的关系。［结果］ SUVmax、SULmax与DLBCL患者年龄、分期、Hans分型、结外病变个数及Ki-67间无相关性（P均＞0.05）。取SUVmax、SULmax、MTV、TLG中位数（分别为18.64、17.65、22.74、221.84）为界值，单因素分析显示Ann Arbor 分期、结外病变个数、Hans分型、 SULmax是患者 PFS 的影响因素（P均＜0.05）；多因素分析显示Ann Arbor 分期、结外病变个数、Hans分型是患者 PFS 的独立影响因素（P均＜0.05）。［结论］ 治疗前PET-CT定量参数对DLBCL患者预后预测意义不明确，目前还不能通过其来判断预后或指导治疗。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the correlation of quantitative PET-CT parameters with prognosis of patients with diffuse large B-cell lymphoma (DLBCL). ［Methods］ The clinical and imaging data of 116 patients with DLBCL were retrospectively analyzed. All patients underwent 18F-FDG PET/CT examination before treatment and had complete clinical follow-up data. The relationship between metabolic parameters of PET-CT and prognostic factors，short-term efficacy and long-term survival was evaluated. ［Results］ SUVmax，SULmax had no correlation with age，stage，Hans type，number of extranodal lesions，and Ki-67(all P>0.05). Taking the median values of SUVmax，SULmax，MTV，and TLG (18.64， 17.65，22.74，221.84，respectively) as the cut-off values，univariate analysis found that Ann Arbor stage，number of extranodal lesions，Hans type，and SULmax were associated with PFS of patients (all P<0.05)；multivariate analysis results showed that Ann Arbor staging，number of extranodal lesions，and Hans type were independent factors of PFS(all P<0.05). ［Conclusion］ The study shows that the significance of PET-CT quantitative parameters before treatment in prognosis of DLBCL patients is not clear，and it may not be used to judge prognosis or guide treatment for DLBCL patients. |
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