| 赵 雪,孙 思,龚金玲.CEUS参数定量分析在乳腺癌新辅助化疗疗效中的预测价值[J].肿瘤学杂志,2020,26(9):780-783. |
| CEUS参数定量分析在乳腺癌新辅助化疗疗效中的预测价值 |
| Contrast-enhanced Ultrasound Parameters in Prediction of Response to Neoadjuvant Chemotherapy in Breast Cancer Patients |
| 投稿时间：2020-01-13 |
| DOI：10.11735/j.issn.1671-170X.2020.09.B006 |
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| 中文关键词: 乳腺癌 超声增强造影 新辅助化疗 预测效能 |
| 英文关键词:breast cancer contrast-enhanced ultrasound neoadjuvant chemotherapy prediction |
| 基金项目:国家自然科学基金面上项目（81371553） |
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| 摘要点击次数: 858 |
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| 中文摘要: |
| 摘 要：［目的］ 探究CEUS指标对乳腺癌患者新辅助化疗(neoadjuvant chemotherapy，NAC)疗效的预测价值。［方法］ 选择2018年10月至2019年5月在陆军军医大学第二附属医院行NAC治疗的乳腺癌患者51例，均使用紫杉醇联合顺铂治疗，于NAC治疗结束后行CEUS，并于1周内行手术切除，根据术后病理切片是否达到病理完全缓解（pCR）将患者分为反应组与对照组，对比两组CEUS结果，应用ROC曲线评估CEUS指标对疗效的预测价值。［结果］ 本研究共有16例（31.37%）达pCR；反应组峰值强度、区域血流量及肿瘤直径显著性小于对照组（P均<0.05），平均通过时间显著性大于对照组（t=2.351，P=0.023）；峰值强度、区域血流量、平均通过时间、肿瘤直径在最佳截点预测NAC疗效的AUC分别为0.888、0.821、0.923和0.941，各指标间无显著性差异（P＞0.05）；肿瘤直径的预测特异性显著性高于区域血流量（97.14% vs 77.14%；χ2=6.248，P=0.012）。［结论］ CEUS定量分析对于乳腺癌患者NAC疗效具有较好预测价值，值得进一步研究探讨。 |
| 英文摘要: |
| Abstract：［Objective］ To evaluate the contrast-enhanced ultrasound(CEUS) parameters in prediction of response to neoadjuvant chemotherapy(NAC) in breast cancer patients. ［Methods］ From October 2018 to May 2019，51 breast cancer patients who received NAC treatment in the Second Affiliated Hospital of PLA Army Medical University were enrolled. All patients were treated with paclitaxel combined with cisplatin for NAC，CEUS was performed after NAC treatment and surgical resection was performed within 1 week. The pathological complete response(pCR) was reached in 16 patients(response group) and not reached in 35 patients(non-response group). CEUS results of the two groups were compared，and the predictive value of CEUS indicators for response was evaluated by ROC curve. ［Results］ The peak intensity，regional blood flow and diameter of the response group were significantly lower than those of non-response group(all P<0.05)，and the average transit time was significantly higher than that of non-response group(t=2.351，P=0.023). The areas under the ROC curve(AUCs) of peak intensity，regional blood flow，mean transit time and diameter for predicting response to NAC was 0.888，0.821， 0.923 and 0.941，respectively，there was no significant difference among the CEUS parameters(P>0.05)，and the predictive specificity of diameter was significantly higher than regional blood flow(97.14% vs 77.14%；χ2=6.248，P=0.012). ［Conclusion］ CEUS parameters have a good predictive value for response to NAC in breast cancer patients. |
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