| 李晓琴,宋丽娟,何 欣.349例新辅助化疗后乳腺浸润性导管癌嗜神经侵袭与临床病理特征间的关系[J].肿瘤学杂志,2020,26(9):776-779. |
| 349例新辅助化疗后乳腺浸润性导管癌嗜神经侵袭与临床病理特征间的关系 |
| Relation of Perineural Invasion and Clinicopathological Characteristics in 349 Cases with Breast Invasive Ductal Carcinoma After Neoadjuvant Chemotherapy |
| 投稿时间：2020-03-26 |
| DOI：10.11735/j.issn.1671-170X.2020.09.B005 |
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| 中文关键词: 乳腺癌 嗜神经侵袭 新辅助化疗 |
| 英文关键词:breast cancer perineural invasion neoadjuvant chemotherapy |
| 基金项目:甘肃省自然科学基金（17JR5RA044） |
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| 摘要点击次数: 1467 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨新辅助化疗后乳腺浸润性导管癌嗜神经侵袭（perineural invasion，PNI）与患者临床病理特征之间的关系。［方法］ 收集甘肃省肿瘤医院349例乳腺浸润性导管癌患者的临床和病理资料，所有患者均接受术前新辅助化疗，分析PNI发生与临床病理特征之间的关系。［结果］ 新辅助化疗后349例患者中PNI阳性91例（35%），PNI阴性258例（65%）。单因素结果显示，乳腺浸润性导管癌神经侵犯与腋下淋巴结转移、淋巴结转移数目、TNM分期、脉管侵犯、分子分型和组织学分级有关（均P<0.05），而与年龄、肿瘤直径、Ki-67增殖指数、化疗后反应、ER、 PR及Her-2表达无关（均P>0.05）。多因素Logistic 回归分析显示，分子分型和组织学分级是PNI阳性的危险因素（P<0.05）。［结论］ 新辅助化疗后乳腺浸润性导管癌神经侵犯与腋下淋巴结转移、淋巴结转移数目、TNM分期、脉管侵犯、分子分型和组织学分级有关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relation of the perineural invasion(PNI) and the clinicopathological characteristics in patients with invasive breast ductal carcinoma after neoadjuvant chemotherapy. ［Methods］ The clinical and pathological data of 349 patients with breast invasive ductal carcinoma who were admitted in Gansu Provincial Cancer Hospital and received preoperative neoadjuvant chemotherapy were collected. The relationship of the incidence of PNI with clinical and pathological characteristics was analyzed. ［Results］ Among the 349 patients after neoadjuvant chemotherapy，PNI occurred in 91 cases(35%，PNI-positive) and did not occur in 258 cases(65%，PNI-negative). Univariate analysis showed that perineural invasion of breast invasive ductal carcinoma was related to the axillary lymph node metastasis，number of lymph node metastases，TNM staging，vascular invasion，molecular typing and histological grade(all P<0.005) ，but was not related to age，tumor diameter，Ki-67 proliferation index，response to chemotherapy，ER，PR，Her-2 expression(all P>0.05). Multivariate Logistic regression analysis showed that molecular typing and histological classification were risk factors for PNI positive(P<0.05). ［Conclusion］ Perineural invasion of breast invasive ductal carcinoma after neoadjuvant chemotherapy is correlated with the molecular typing and histological classification of patients. |
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