| 姜 聪,张世园,黄元夕.系统免疫炎症指数与Luminal B型乳腺癌新辅助化疗病理完全缓解的关系[J].肿瘤学杂志,2020,26(9):767-771. |
| 系统免疫炎症指数与Luminal B型乳腺癌新辅助化疗病理完全缓解的关系 |
| Relationship Between Systemic Immune-Inflammation Index and Pathological Complete Response in Luminal B Breast Cancer Received Neoadjuvant Chemotherapy |
| 投稿时间：2020-04-02 |
| DOI：10.11735/j.issn.1671-170X.2020.09.B003 |
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| 中文关键词: 系统免疫炎症指数 Luminal B型乳腺癌 新辅助化疗 病理完全缓解 |
| 英文关键词:systemic inflammatory index Luminal B breast cancer neoadjuvant chemotherapy pathological complete response |
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| 中文摘要: |
| 摘 要：［目的］ 探讨系统免疫炎症指数（systemic inflammation index，SII）与Luminal B型乳腺癌新辅助化疗病理完全缓解（pathological complete response，pCR）的关系。［方法］ 回顾性分析2015年1月至2017年1月在哈尔滨医科大学附属肿瘤医院198例接受新辅助化疗及手术的女性Luminal B型乳腺癌患者的临床病理资料。采用Logistic回归模型进行单因素和多因素分析SII与pCR的关系。［结果］ 37例患者获pCR，低SII组25例，高SII组12例，SII与pCR相关（P=0.018）。单因素分析显示：与Her-2阴性者相比，阳性者pCR更高(P<0.001)；与Ki-67≤14%者相比，Ki-67＞14%者更易达到pCR(P=0.024)；与低SII组相比，高SII组更难达到pCR(P=0.020)。多因素分析显示：与低SII组相比，高SII组较难获得pCR(P=0.019)；与Her-2阴性者相比，Her-2阳性者pCR率更高(P=0.024)；与Ki-67≤14%者相比，Ki-67＞14%者pCR率更高(P=0.019)。 亚组分析显示：在低SII组中Luminal B/Her-2(+)亚组患者pCR率更高（χ2=9.764，P=0.002）；在高SII组中Luminal B/Her-2(+)亚组患者pCR率更高，但差异无统计学意义（χ2=3.556，P=0.059）。［结论］ SII值、Ki-67值及Her-2状态是Luminal B型乳腺癌新辅助化疗后pCR的独立预测因素，低SII且Luminal B/Her-2(+)组pCR率更高，与预后相关性有待进一步研究。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between systemic inflammation index(SII) and pathological complete response(pCR) of Luminal B breast cancer. ［Methods］ The clinicopathological data of 198 female patients with Luminal B breast cancer who received neoadjuvant chemotherapy and surgery in the cancer hospital affiliated to Harbin medical university from January 2015 to January 2017 were retrospectively analyzed. Logistic regression model was used to analyze the relationship between SII and pCR in breast cancer. ［Results］ 37 patients (18.7%) got pCR，which 25 in the low SII group and 12 in the high SII group. SII was correlated with pCR (P=0.018). Univariate analysis showed that pCR was higher in the positive Her-2 group than in the negative Her-2 group (P<0.001). Compared to Ki-67 ≤14% group，> 14% group were easy to achieve pCR(P=0.024). Compared to the low SII group，the high SII group was more difficult to achieve pCR(P=0.020). Multivariate analysis showed that pCR was more difficult to obtain in the high SII group than in the low SII group (P=0.019). Compared to the Her-2 negative group，the positive group had a higher pCR rate (P=0.024). Compared to Ki-67 ≤14%，> 14% had a higher pCR rate (P=0.019). For the low SII group，the Luminal B/ Her-2 (+) subgroup had a higher pCR rate (?字2=9.764，P=0.002). For the high SII group，the Luminal B/ Her-2 (+) subgroup had a higher pCR rate，but the difference was not statistically significant(?字2=3.556，P=0.059). ［Conclusion］ SII value，Ki-67 value and Her-2 status are independent predictors of pCR for Luminal B breast cancer with NAC，Low SII and Luminal B/ Her-2 (+) subgroup has higher pCR rate， and its correlation with prognosis of patients needs further study. |
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