| 尉浩斌,张小丹,李苏宜.影响肿瘤患者肠屏障功能临床因素分析[J].肿瘤学杂志,2020,26(8):716-721. |
| 影响肿瘤患者肠屏障功能临床因素分析 |
| Clinical Determinants of Intestinal Barrier Status in Cancer Patients |
| 投稿时间：2020-01-13 |
| DOI：10.11735/j.issn.1671-170X.2020.08.B011 |
|
 |
| 中文关键词: 肿瘤 营养不良 肠道屏障功能 D?鄄乳酸 DAO 内毒素 |
| 英文关键词:tumor malnutrition intestinal barrier function D?鄄lactic acid DAO bacterial endotoxin |
| 基金项目: |
|
| 摘要点击次数: 1154 |
| 全文下载次数: 270 |
| 中文摘要: |
| 摘 要：［目的］ 探讨肿瘤患者肠道屏障功能的临床影响因素。［方法］ 分析162例在院肿瘤患者的血浆二胺氧化酶（DAO）、D-乳酸、细菌内毒素水平的数据，结合患者的临床特征，分析其对肠道屏障功能的影响。［结果］ 162例患者中，74例（45.68%）DAO值在正常范围内，88例升高（54.32%）；89例（54.94%）D-乳酸值在正常范围内，73例升高（45.06%）；145例（89.51%）细菌内毒素值在正常范围内，17例升高（10.49%）。单因素分析结果显示，营养不良C级、大便习惯改变、合并肠梗阻、合并感染患者的DAO、细菌内毒素水平显著升高（P均＜0.05）；大便习惯改变、合并肠梗阻、合并感染患者的D-乳酸水平显著升高（P均＜0.05）。多因素Logistic回归分析结果显示，大便习惯改变是导致肿瘤患者血浆D-乳酸水平升高的独立影响因素（OR=11.712，95%CI：4.420~31.034，P<0.05），感染是导致肿瘤患者血浆细菌内毒素水平升高的独立影响因素（OR=3.280，95%CI：1.009~10.664，P<0.05）。［结论］ 大便习惯改变、感染分别为影响肿瘤患者血浆D-乳酸、细菌内毒素水平的独立影响因素。 |
| 英文摘要: |
| Abstract：［Objective］ To explore the clinical influencing factors of intestinal barrier function in cancer patients. ［Methods］ One hundred and sixty-two cancer patients were enrolled. Serum levels of Diamine oxidase(DAO)，D-lactic acid and bacterial endotoxin were measured，and influencing factors of intestinal barrier function were analyzed. ［Results］ In 162 patients，DAO levels were increased in 88 cases(54.32%)，D-lactic acid levels were increased in 73(45.06%) and bacterial endotoxin levels were increased in 17(10.49%). Univariate analysis showed that the levels of serum DAO and bacterial endotoxin were significantly elevated in patients with grade C malnutrition，change of defecation habit，intestinal obstruction and infection(all P<0.05)，while the levels of serum D-lactic acid were significantly elevated in patients with change of defecation habit，intestinal obstruction and infection(all P<0.05). The multivariate Logistic regression analysis showed that change of defecation habit was an independent influencing factor for the high levels of D-lactic acid(OR=11.712，95%CI：4.420~31.034，P<0.05)，while infection was an independent influencing factor for the high levels of bacterial endotoxin in cancer patients(OR=3.280，95%CI：1.009~10.664，P<0.05). ［Conclusion］ Change of defecation habit and infection are the independent influencing factors for the levels of D-lactic acid and bacterial endotoxin，respectively. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |