| 王佳美,刘欣跃.CAV-1基因多态性与散发乳腺癌易感性的相关性分析[J].肿瘤学杂志,2020,26(7):621-625. |
| CAV-1基因多态性与散发乳腺癌易感性的相关性分析 |
| Relationship Between Single Nucleotide Polymorphisms of CAV-1 Gene and Susceptibility of Sporadic Breast Cancer |
| 投稿时间：2019-11-19 |
| DOI：10.11735/j.issn.1671-170X.2020.07.B011 |
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| 中文关键词: 散发性乳腺癌 CAV-1基因 基因多态性 易感性 |
| 英文关键词:sporadic breast cancer CAV-1 gene gene polymorphism susceptibility |
| 基金项目:甘肃省卫生行业科研计划项目（GSWSKY2017-31 ）；兰州大学第二医院“萃英科技创新”计划项目（CY2017-MS17） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨CAV-1基因多态性与散发乳腺癌的相关性。［方法］ 采用病例对照研究，纳入经病理确诊的135例女性乳腺癌患者作为实验组，166例女性健康体检者为对照组。通过竞争性等位基因特异性PCR法对研究对象基因位点进行分型；采用χ2检验比较CAV-1各SNP基因型及等位基因频率在两组中的分布差异；非条件Logistic回归分析CAV-1基因多态性与乳腺癌易感性的关联。［结果］ 在共显性模型、显性模型及等位基因模型下rs3807987及rs7804372位点多态性与乳腺癌易感性密切相关。rs3807987：相对于GG基因型，AG、AA基因携带者（AG/AA基因型）均增加乳腺癌的发病风险（P＜0.05），OR值分别为2.110（95%CI：1.270~3.505）、1.968（95%CI：1.205~3.216）。rs7804372位点：相对于TT基因型，AT、AA基因携带者（AT/AA基因型）均增加乳腺癌的发病风险（P＜0.05），OR值分别为2.088（95%CI：1.285~3.392）、2.059（95%CI：1.293~3.280）。rs12672038位点：在共显性模型、显性模型、等位基因模型均未见rs12672038位点多态性分布与乳腺癌发病风险之间存在相关性。［结论］ CAV-1基因rs3807987与rs7804372多态性与乳腺癌易感性相关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the association of CAV-1 polymorphisms with the risk of sporadic breast cancer. ［Methods］ Competitive allele specific PCR(KASP) was performed to identify the genotypes of CAV-1 polymorphisms in 135 female breast cancer patients(study group)，and 166 healthy women(control group). The distribution of CAV-1 SNP genotype and allele frequency were compared by Chi-square test，and unconditioned Logistic regression was used to analysis the relationship between CSV-1 gene polymorphisms and susceptibility of breast Cancer. ［Results］ The co-dominant model，dominant model and allelic model showed a significant association of CAV-1 gene rs3807987 and rs7804372 with the risk of breast cancer（all P＜0.05）. The risk of breast cancer was increased in women with rs3807987 AG，or AG/AA genotypes compared to those with GG genotype(OR=2.110，95%CI：1.270~3.505，P<0.05; OR=1.968，95%CI：1.205~3.216，P<0.05），respectively；and increased in women with rs7804372 AT，AT/AA genotypes compared to those with TT genotype(OR=2.088，95%CI：1.285~3.392，P<0.05; OR=2.059，95%CI：1.293~3.280，P<0.05) ，respectively. No significant association of rs12672038 polymorphism with risk of breast cancer was found in co-dominant model，dominant model or allele model. ［Conclusion］ The polymorphisms of CAV-1 gene rs3807987 and rs7804372 are associated with susceptibility to sporadic breast cancer. |
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