| 胡文献,吕可真,陈永霞.Krüppel样因子4在肺癌中的研究进展[J].肿瘤学杂志,2020,26(7):600-603. |
| Krüppel样因子4在肺癌中的研究进展 |
| Progress of Krüppel-like Factor 4 in Lung Cancer |
| 投稿时间：2019-12-15 |
| DOI：10.11735/j.issn.1671-170X.2020.07.B007 |
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| 中文关键词: Krüppel样因子4 肺癌 表达 机制 |
| 英文关键词:Krüppel-like factor 4 lung cancer expression mechanism |
| 基金项目:国家自然科学基金（81000996）；浙江省自然科学基金（LY15H160020) |
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| 中文摘要: |
| 摘 要：Krüppel样因子4（Krüppel-like factor 4，KLF4）是一种进化保守的能够通过结合特异蛋白进行转录调控的Krüppel样因子（Krüppel-like factors，KLFs），其在组织细胞生长、分化进程中发挥重要作用。KLF4不仅在多种肿瘤细胞与组织中表现出不同程度的差异表达，而且在肿瘤发生发展的进程中起着重要的作用。对KLF4在肺癌中的差异表达和作用机制进行总结梳理，并探寻其作为诊断标志物或治疗靶点的可能性具有重大临床意义。全文综述KLF4在肺癌中的差异表达及潜在的分子机制，为进一步揭示肺癌的发生发展机制提供参考。 |
| 英文摘要: |
| Abstract：Krüppel-like factor 4(KLF4) belongs to an evolutionarily conserved Krüppel-like factor(KLFs) family that regulates gene transcription by binding specific proteins. It plays an important role in the cell growth and differentiation. KLF4 is expressed in various tumor cells at different degrees and is involved in the process of tumorigenesis and development. Recent researches have revealed that the expression of KLF4 is associated with the clinicopathological features of lung cancer. Therefore it is of clinical significance to explore its application as a diagnostic marker or therapeutic target for lung cancer. This article reviews the differential expression of KLF4 in lung cancer and its underlying molecular mechanism，to provide a reference for further studies. |
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