| 冼海兵,冯卫能,张 华.miR-155与SOCS1在非小细胞肺癌中表达及临床意义[J].肿瘤学杂志,2020,26(7):586-590. |
| miR-155与SOCS1在非小细胞肺癌中表达及临床意义 |
| Expression of miR-155 and SOCS-1 in Non-small Cell Lung Cancer and Its Clinical Significance |
| 投稿时间：2019-09-04 |
| DOI：10.11735/j.issn.1671-170X.2020.07.B004 |
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| 中文关键词: 非小细胞肺癌 miR-155 细胞因子信号传导抑制因子1 |
| 英文关键词:non-small cell lung cancer miR-155 suppressor of cytokine signaling 1 |
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| 中文摘要: |
| 摘 要：［目的］ 研究非小细胞肺癌（non-small-cell lung cancer，NSCLC）癌组织中微小RNA（microRNA，miR）-155及细胞因子信号传导抑制因子1（suppressor of cytokine signaling 1，SOCS1）的表达及其临床意义。［方法］ 应用荧光实时定量PCR（quantitative real-time PCR，qRT-PCR）检测96例NSCLC癌组织和瘤旁组织中miR-155与SOCS1的表达。统计分析不同组间miR-155与SOCS1表达差异及其与临床病理特征之间的关系。Cox比例风险模型分析影响NSCLC患者预后的危险因素。［结果］ 癌组织与癌旁组织miR-155相对表达量分别为3.13±0.31、1.05±0.22，SOCS1相对表达量分别为1.26±0.25、4.02±0.33。与癌旁组织相比，NSCLC癌组织中miR-155表达明显较高，而SOCS1表达明显较低（P均<0.05）。癌组织中miR-155及SOCS1表达与肿瘤分期有关（P＜0.05），而与性别、年龄、病理类型、肿瘤大小、组织学分级及淋巴结转移无关（P均>0.05）。96例NSCLC患者随访3～36个月，中位随访时间23.2个月，高miR-155表达组患者3年OS明显低于低表达组（χ2=4.315，P=0.034），低SOCS1表达组患者3年OS明显低于高表达组（χ2=3.924，P=0.048）。NSCLC癌组织中高miR-155表达、低SOCS1表达、高肿瘤TNM分期是影响患者生存预后的独立危险因素。［结论］ NSCLC癌组织中miR-155表达升高，SOCS1表达降低，两者均与与肿瘤分期有关，有希望成为NSCLC新的肿瘤标志物。 |
| 英文摘要: |
| Abstract： ［Objective］ To investigate the expression and clinical significance of microRNA(miR)-155 and suppressor of cytokine signaling 1(SOCS1) in non-small-cell lung cancer(NSCLC) cancer tissues. ［Methods］ The expression of miR-155 and SOCS1 in 96 specimens of NSCLC tissues and pericancerous tissues were detected by real-time quantitative PCR(qRT-PCR). The expressions of miR-155 and SOCS1 and their relationship with clinicopathological features were analyzed. The Cox proportional hazards model was used to analyze the risk factors related to the prognosis of patients with NSCLC. ［Results］ The relative expression of miR-155 was significantly higher in NSCLC tissues(3.13±0.31 vs. 1.05±0.22，P<0.05)，while the expression of SOCS1 was significantly lower(1.26±0.25 vs. 4.02±0.33，P<0.05) than those in pericancerous tissues. The expression of miR-155 and SOCS1 in cancer tissues was correlated with tumor stage(P<0.05)，but not related to gender，age，pathological type，tumor size，histological grade and lymph node metastasis(P all>0.05). Kaplan-Meier analysis showed that the 3-year overall survival(OS) of high miR-155 expression group was significantly lower than that of low miR-155 expression group(χ2=4.315，P=0.034)，while the 3-year OS of low SOCS1 expression group was significantly lower than that of high SOCS1 expression group(χ2=3.924，P=0.048). High miR-155 expression，low SOCS1 expression in NSCLC cancer tissues and high tumor TNM stage were independent risk factors for poorer survival in NSCLC patients. ［Conclusion］ The expression of miR-155 is increased and the expression of SOCS1 is decreased in NSCLC tissues. Both of them are related to tumor stage and may be used as a new tumor marker of NSCLC. |
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