| 陈 维,朱 玮,吕成余.LASS2/TMSG-1、TAK1和TAB1在结肠癌中的表达及临床意义[J].肿瘤学杂志,2020,26(6):511-516. |
| LASS2/TMSG-1、TAK1和TAB1在结肠癌中的表达及临床意义 |
| Expression and Clinical Significance of LASS2/TMSG -1，TAK1 and TAB1 in Colon Cancer |
| 投稿时间：2019-07-03 |
| DOI：10.11735/j.issn.1671-170X.2020.06.B009 |
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| 中文关键词: 结肠肿瘤 LASS2/TMSG-1 TAK1 TAB1 |
| 英文关键词:colon cancer LASS2/TMSG-1 TAK1 TAB1 |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肿瘤转移抑制基因-1（LASS2/TMSG-1）、转化生长因子激活激酶1（TAK1）和转化生长因子β活化激酶结合蛋白1（TAB1）在结肠癌组织中的表达及其临床意义。［方法］ 选取2017年1月至2018年2月在我院治疗的原发性结肠癌患者68例，分别取其结肠癌组织及癌旁正常组织，采用实时聚合酶联法（real-time polymerase chain reaction，RT-PCR）测定组织中的LASS2/TMSG-1、TAK1、TAB1表达水平，分析结肠癌组织中LASS2/TMSG-1、TAK1、TAB1的表达水平以及与患者临床病理特征的相关性，采用COX回归分析分析LASS2/TMSG-1、TAK1、TAB1表达水平与患者预后的相关性。［结果］ 结肠癌患者结肠癌组织TAK1（0.76±0.15ng/ml）、TAB1（1.46±0.20ng/ml）的表达水平与癌旁正常组织（0.57±0.15ng/ml，1.21±0.19ng/ml）相比显著升高；LASS2/TMSG-1的表达水平（1.52±0.36ng/ml）与癌旁正常组织（2.36±0.43ng/ml）相比显著下降（P<0.05）。LASS2/TMSG-1、TAK1、TAB1表达水平与肿瘤分化程度、TNM分期显著相关（P<0.05）。术后12个月随访时共有8例（11.76%）患者出现肿瘤复发/转移。出现肿瘤复发/转移的患者其TAK1、TAB1水平（0.96±0.15ng/ml，1.68±0.19ng/ml）与未复发/转移（0.52±0.13ng/ml，1.26±0.20ng/ml）患者相比显著升高；LASS2/TMSG-1显著下降（1.74±0.38ng/ml vs 3.02±0.49ng/ml）（P<0.05）。COX回归分析结果显示，肿瘤分化程度、肿瘤TNM分期、LASS2/TMSG-1、TAK1及TAB1表达水平是影响结肠癌患者临床预后的独立因素。LASS2/TMSG-1、TAK1、TAB1表达水平之间无显著相关性（P>0.05）；患者预后与LASS2/TMSG-1、TAK1、TAB1表达水平具有显著相关性（P<0.05）。［结论］ LASS2/TMSG-1、TAK1、TAB1的表达水平可能与结肠癌的发生及发展具有相关性，且与患者临床预后相关。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression and clinical value of tumor metastasis suppressor gene-1(LASS2/TMSG-1)，transforming growth factor activates kinase 1(TAK1) and transforming growth factor activated kinase binding protein 1(TAB1) in colon cancer. ［Methods］ The colon cancer tissues and normal colon tissue samples were collected from 68 patients with colon cancer. The real-time polymerase chain reaction(RT-PCR) was utilized to analyze the mRNA expression level of LASS2/TMSG-1，TAK1 and TAB1. The relationship of the expression level of LASS2/TMSG-1，TAK1，TAB1 with clinical pathological features and prognosis of patients was analyzed. ［Results］ The expression level of TAK1(0.76±0.15ng/ml)，TAB1(1.46±0.20ng/ml) in colon cancer tissues was significantly higher than that in normal tissues(0.57±0.15ng/ml，1.21±0.19ng/ml)，while the level of LASS2/TMSG-1(1.52±0.36 ng/ml) was significantly lower than that in normal tissues(2.36±0.43 ng/ml)(P<0.05). The expression level of LASS2/TMSG-1，TAK1，TAB1 was significantly correlated with tumor differentiation and TNM stage(P<0.05). There was 8 patients(11.76%) developed tumor recurrence/metastasis at 12 months of follow-up. The level of TAK1，TAB1 of patients with tumor recurrence/metastasis(0.96±0.15ng/ml，1.68±0.19ng/ml)were significantly higher than those without tumor recurrence/metastasis(0.52±0.13ng/ml，1.26±0.20ng/ml)，while the level of LASS2/TMSG-1 of patients with tumor recurrence/metastasis were significantly lower than those without tumor recurrence/metastasis(1.74±0.38ng/ml vs 3.02±0.49ng/ml)(P<0.05). Tumor differentiation degree，TNM stages，the LASS2/TMSG-1，TAK1，TAB1 level was the independent factors of colon cancer analyze by COX Regression analysis. There was no significant correlation between LASS2/TMSG-1，TAK1 and TAB1(P>0.05). The prognosis of patients was significantly correlated with the expression levels of LASS2/ TMSG-1，TAK1 and TAB1(P<0.05).［Conclusions］ The expression levels of LASS2/TMSG-1，TAK1 and TAB1 may be correlated with the occurrence and development of colon cancer，as well as related to the clinical prognosis of patients. |
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