李立文,卜晓敏,夏 亮.核转录因子E2相关因子2在肿瘤血管生成调控中的研究进展[J].肿瘤学杂志,2020,26(5):433-437. |
核转录因子E2相关因子2在肿瘤血管生成调控中的研究进展 |
Research Progress on Regulation of Nrf2 in Tumor Angiogenesis |
投稿时间:2019-12-02 |
DOI:10.11735/j.issn.1671-170X.2020.05.B013 |
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中文关键词: 核转录因子E2相关因子2 活性氧簇 缺氧 炎症因子 肿瘤血管生成 |
英文关键词:nuclear transcription factor E2-related factor 2 reactive oxygen species hypoxia inflammatory factor tumor angiogenesis. |
基金项目:国家自然科学基金青年基金项目(81502147);浙江省医药卫生科技项目(2017KY260);浙江省肿瘤医院青年科研基金(QN201803) |
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中文摘要: |
摘 要:研究发现核转录因子E2相关因子2(Nrf2)在多种肿瘤中异常表达,并通过氧化应激、HO-1通路、缺氧及炎症介质等多种途径参与调控肿瘤血管生成过程。对Nrf2与肿瘤血管生成的相关性进行探究,有助于发现抗肿瘤血管生成治疗的新靶点。全文就近年来肿瘤血管生成与Nrf2信号通路相关研究进展作一综述。 |
英文摘要: |
Abstract:Abnormal expression of nuclear transcription factor E2- related factor 2(Nrf2) has been found in many types of cancers and is involved in regulating tumor angiogenesis through oxidative stress,HO-1 pathway,hypoxia and inflammatory mediators. To explore the correlation between Nrf2 and tumor angiogenesis is helpful to find new targets for anti-tumor angiogenesis therapy. This article reviews the recent advances in tumor angiogenesis through Nrf2-related signaling pathways. |
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