| 马睿玲,王新斌,张秋菊.长链非编码RNA调控肝癌干细胞的作用[J].肿瘤学杂志,2020,26(4):341-345. |
| 长链非编码RNA调控肝癌干细胞的作用 |
| Long Non-coding RNA Regulates Liver Cancer Stem Cells |
| 投稿时间：2019-03-26 |
| DOI：10.11735/j.issn.1671-170X.2020.04.B013 |
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| 中文关键词: 长链非编码RNA 肝癌干细胞 肝肿瘤 |
| 英文关键词:Long non-coding RNA liver cancer stem cells liver cancer |
| 基金项目:甘肃省自然科学基金项目（1508RJZA017） |
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| 摘要点击次数: 1975 |
| 全文下载次数: 366 |
| 中文摘要: |
| 摘 要：目前常规疗法对晚期、转移或复发肝癌患者疗效差。肝癌干细胞（LCSCs）参与肝癌的发展、侵袭、转移和耐药，与不良预后密切相关，被认为是肝癌治疗的重要靶点。长链非编码RNA（LncRNA）在肝癌中异常表达。最近的研究表明，lncRNAs可能在调控LCSCs的生物学功能中发挥重要作用。全文总结lncRNA调控LCSCs作用的研究现状。 |
| 英文摘要: |
| Abstract：Conventional therapies have very limited efficacy for advanced，metastatic or recurrent liver cancer patients. The liver cancer stem cells(LCSCs) are involved in the development，invasion，metastasis and drug resistance of hepatocellular carcinoma，and are closely related to the poor prognosis of patients. Therefore the LCSCs are considered as an important target for the treatment of liver cancer. Long non-coding RNA(LncRNA) is abnormally expressed in liver cancer. Recent studies have shown that LncRNAs may play an important role in regulating the biological function of LCSCs. In this review，the current research advances on the role of LncRNA in the regulation of LCSCs are summarized. |
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