| 王小洁,李丽燕.肝细胞癌患者血清miR-4686表达及意义[J].肿瘤学杂志,2020,26(4):309-312. |
| 肝细胞癌患者血清miR-4686表达及意义 |
| Expression of miR-4686 in Hepatocellular Carcinoma and Its Clinical Significance |
| 投稿时间：2019-08-02 |
| DOI：10.11735/j.issn.1671-170X.2020.04.B007 |
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| 中文关键词: miR-4686 肝细胞癌 表达 |
| 英文关键词:miR-4686 hepatocellular carcinoma expression |
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| 中文摘要: |
| 摘 要：［目的］ 探讨miR-4686在肝细胞癌（HCC）患者血清中的表达及与临床病理特征的关系。［方法］ 收集57例肝细胞癌患者血清，同时收集慢性乙肝患者32例、健康体检者30例为对照组，RT-qPCR法检测血清中miR-4686的相对表达量，分析miR-4686在HCC、慢性乙肝与正常对照者间的差异；分析miR-4686表达与HCC患者临床病理特征的关系。［结果］miR-4686在HCC组、慢性乙肝组、正常对照组的表达量分别为3.72±1.03、1.59±0.44、1.37±0.38，HCC组表达水平显著高于慢性乙肝组与正常对照组（P=0.015、0.011），慢性乙肝组与正常对照组间差异无统计学意义（P=0.873）。miR-4686表达水平与HCC患者分化程度、血管侵犯、TMN分期及APF水平有关（P均<0.05）。［结论］ miR-4686在HCC患者血清的表达水平上升，可判断HCC的恶性程度。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of miR-4686 in serum of patients with hepatocellular carcinoma(HCC) and its relationship with clinicopathological characteristics of HCC. ［Methods］ The serum samples were collected from 57 HCC patients，and 32 patients with chronic hepatitis B(CHB) and 30 healthy subjects(control group). The relative expression of miR-4686 in three groups was detected by real-time fluorescence quantitative polymerase chain reaction(qRT-PCR). The relationship between miR-4686 expression and clinicopathological characteristics of HCC patients was analyzed. ［Results］ The expression level of miR-4686 in HCC group was significantly higher than those in CHB group and control group(3.72±1.03 vs 1.59±0.44，1.37±0.38，P=0.015，0.011)，while there was no significant difference in miT-4686 expression between CHB group and control group(P=0.873). The expression level of miR-4686 was correlated with differentiation degree，vascular invasion，TMN stage and APF level of HCC patients(all P<0.05). ［Conclusion］ The serum expression level of miR-4686 in HCC patients is up-regulated，which is correlated with the malignant degree of HCC. |
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