| 张煜婕,陈 杰,陈涵波.调强放疗时代诱导化疗在Ⅱ~Ⅳa期鼻咽癌中的研究进展[J].肿瘤学杂志,2020,26(4):289-294. |
| 调强放疗时代诱导化疗在Ⅱ~Ⅳa期鼻咽癌中的研究进展 |
| Research Progress of Induction Chemotherapy for Stage Ⅱ~Ⅳa Nasopharyngeal Carcinoma in the Era of Intensity-modulated Radiotherapy |
| 投稿时间：2019-11-05 |
| DOI：10.11735/j.issn.1671-170X.2020.04.B004 |
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| 中文关键词: 鼻咽肿瘤 调强放疗 诱导化疗 Ⅱ~Ⅳa期 |
| 英文关键词:nasopharyngeal carcinoma intensity-modulated radiotherapy induction chemotherapy stage Ⅱ~Ⅳa |
| 基金项目:国家自然科学基金（81672989）；医院科研基金重点项目(ZK201602)；院优才计划，院青年专业技术人才培养经费(2017YYCJH-02)；中国博士后科学基金(2018M632266)；博士后科研经费 (SZL201705) |
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| 中文摘要: |
| 摘 要：调强放射治疗的应用使得鼻咽癌的生存得到显著改善，但Ⅱ~Ⅳa期鼻咽癌治疗失败的主要原因仍为远处转移。诱导化疗由于具有减轻肿瘤负荷、消除微转移等优势在临床得到广泛关注，但诱导化疗在Ⅱ期鼻咽癌中的应用价值以及在局部晚期鼻咽癌中的最佳治疗模式尚不明确，全文回顾分析近年来诱导化疗联合调强放疗的相关研究，就调强放疗时代诱导化疗在Ⅱ~Ⅳa期鼻咽癌中相关进展作一综述。 |
| 英文摘要: |
| Abstract： The application of intensity-modulated radiotherapy(IMRT) has significantly improved the survival of nasopharyngeal carcinoma(NPC) patients，but distant metastasis remains the main treatment failure mode for stage Ⅱ~Ⅳa NPC. Induction chemotherapy has been widely used in clinical practice due to its advantages of reducing tumor burden and eliminating micro-metastasis. However，the value of induction chemotherapy in stage Ⅱ NPC and the optimal treatment mode of induction chemotherapy in locally advanced NPC are still unclear. This article reviews the progress of induction chemotherapy for stage Ⅱ~Ⅳa NPA in the era of intensity-modulated radiotherapy. |
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