| 冯同富,胡俊波,王 燕.KDM5A表达与卵巢浆液性囊腺癌临床病理因素的关系分析[J].肿瘤学杂志,2020,26(3):216-219. |
| KDM5A表达与卵巢浆液性囊腺癌临床病理因素的关系分析 |
| Relationship Between KDM5A Expression and Clinicopathological Features in Ovarian Serous Cystadenocarcinoma |
| 投稿时间：2019-10-31 |
| DOI：10.11735/j.issn.1671-170X.2020.03.B010 |
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| 中文关键词: 卵巢肿瘤 组蛋白去甲基化酶 KDM5A 生物信息学 |
| 英文关键词:ovarian neoplasms histone demethylase KDM5A bioinformatics |
| 基金项目:湖北省自然科学基金知识创新专项（2018CFC840）；湖北省卫计委联合基金（WJ2018H0158） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨卵巢浆液性囊腺癌中组蛋白赖氨酸去甲基化酶5A（KDM5A）的表达与临床病理因素的关系。［方法］ 利用R2平台的临床数据库对卵巢浆液性囊腺癌临床基因表达芯片数据进行详细分析，从生物信息学角度分析KDM5A表达与临床各参数的相关关系。［结果］ 生信分析结果显示，KDM5A表达与卵巢浆液性囊腺癌的年龄、病理分级、转移及耐药复发密切相关。［结论］ KDM5A的表达和卵巢浆液性囊腺癌的临床病理因素关系密切，其可作为卵巢浆液性囊腺癌病情评估及预后判断的临床参考指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between the expression of histone lysine demethylase 5A(KDM5A) and clinicopathological features in ovarian serous cystadenocarcinoma. ［Methods］ The gene expression microarray data of ovarian serous cystadenocarcinoma were obtained from the clinical database of R2 platform. The relationship between KDM5A expression and clinical parameters was analyzed from the perspective of bioinformatics. ［Results］ The results of bioinformatic analysis indicated that the expression of KDM5A was closely related to the age，pathological grade，metastasis and relapse of ovarian serous cystadenocarcinoma. ［Conclusion］ The expression of KDM5A is closely related to the clinicopathological features of ovarian serous cystadenocarcinoma，and it can be used as a clinical reference index for the evaluation and prognosis of ovarian epithelial carcinoma. |
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