| 魏宇君,黄仲夏.多发性骨髓瘤病情演变和早期诊断研究进展[J].肿瘤学杂志,2020,26(2):2-81. |
| 多发性骨髓瘤病情演变和早期诊断研究进展 |
| Research Progress on Evolution and Early Diagnosis of Multiple Myeloma |
| 投稿时间：2019-07-02 |
| DOI：10.11735/j.issn.1671-170X.2020.02.B001 |
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| 中文关键词: 多发性骨髓瘤 意义未明的单克隆丙种球蛋白血症 病情演变 |
| 英文关键词:multiple myeloma monoclonal gammopathy of undetermined significance evolution |
| 基金项目:北京市卫生和计划生育委员会科技成果和适宜技术推广项目（2018-TG-07）；北京市石景山区医学重点扶持专科建设项目（20170006） |
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| 中文摘要: |
| 摘 要：多发性骨髓瘤（MM）是浆细胞恶性增殖性疾病，引起高钙血症、肾损害、贫血和骨损害等（CRAB症状），又称为症状性MM或活动性MM（AMM）。MM的发病有三个阶段：由意义未明的单克隆丙种球蛋白血症（MGUS）可以演变为无症状骨髓瘤或冒烟型骨髓瘤（SMM），进而进展为症状性MM。在确诊为MGUS前，大部分患者已经历了平均10年的免疫球蛋白升高的过程。目前，虽然靶向新药的应用使MM患者的生存期逐渐延长，但早期识别仍具有挑战性。通过文献学习，发现血清红细胞沉降率、血液黏滞度、血红蛋白水平减低和免疫球蛋白升高等可在MM病情阶段的早期升高，故联合应用一些检测手段对MM进行早期筛查、预防和管理其病情演变必要且可行。 |
| 英文摘要: |
| Abstract：Multiple myeloma(MM) is a malignant plasma cell tumor that causes elevated blood calcium，anemia，kidney damage，and bone destruction(CRAB symptoms)，that is also called symptomatic MM or active MM(AMM). The progress of MM have three stages from MGUS(monoclomal gammopathy of undetermined significance) to SMM(smoldering multiple myeloma) and then to AMM. Most patients have experienced an average of 10 years of elevated immunoglobulin before the diagnosis of MGUS. At present，although the application of new targeted drugs have gradually prolonged the survival of MM patients，early identification is still challenging. Through the literature review，we found that some routine venous blood tests，such as elevated levels of erythrocyte sedimentation rate，blood viscosity，immunoglobulin and decreased hemoglobin levels might identify some patients with early stages MM. Therefore，it is necessary and feasible to jointly apply some testing methods for early screening MM，to prevent and manage the tumor evolution. |
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