| 代月宇,宋启斌,胡伟国.解耦联蛋白UCP1在肿瘤恶病质中的研究进展[J].肿瘤学杂志,2020,26(1):53-57. |
| 解耦联蛋白UCP1在肿瘤恶病质中的研究进展 |
| The Role of Uncoupling Protein 1 in Cancer-associated Cachexia |
| 投稿时间：2019-04-02 |
| DOI：10.11735/j.issn.1671-170X.2020.01.B012 |
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| 中文关键词: 解耦连蛋白 棕色脂肪细胞 癌症恶病质 产热 |
| 英文关键词:uncoupling protein 1 brown adipocyte cancer-associated cachexia produces heat |
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| 摘要点击次数: 1666 |
| 全文下载次数: 313 |
| 中文摘要: |
| 摘 要：解耦连蛋白（UCP1）是一种特殊的线粒体蛋白，能够促进线粒体的呼吸作用而产生热量消耗。UCP1是在棕色脂肪细胞中发现的第一个解耦蛋白，其定位于线粒体内膜，可以降低电子传递系统产生的质子(H+)梯度，更容易直接产生热量。棕色脂肪细胞的UCP1活动被认为是一种很有前途的对抗肥胖和代谢疾病的策略。癌症恶病质是一种以全身炎症、体重减轻、骨骼肌和脂肪组织萎缩为特征的消瘦综合征，其潜在的机制和有限的、可用的治疗选择是不明确的。癌症细胞中棕色脂肪样表型的异常表达先前已被证实与肿瘤生长有关。恶性肿瘤中褐色脂肪相关蛋白的表达可能与肿瘤的预后有关。全文主要从UCP1的表达、解耦联机制以及过程中与恶性肿瘤恶病质之间存在的联系等作一综述。 |
| 英文摘要: |
| Abstract：Uncoupling protein 1(UCP1) is a special mitochondrial protein that promotes mitochondrial respiration and generates heat consumption. Brown adipose tissue(BAT)，on the other hand，is adept at adaptive thermogenesis and directly consumes in the form of heat. It contains a large number of mitochondria and has a high expression of UCP1. UCP1，the first decoupling protein found in brown fat cells，is located in the mitochondrial intima and can reduce the proton(H+) gradient generated by the electron transport system，making it easier to generate heat directly by passing ATP synthase. Due to the oxidative effect of decoupling on stored excess energy，UCP1 activity in brown fat cells is considered as a promising strategy against obesity and metabolic diseases. Cancer-associated cachexia(CAC) is a wasting syndrome characterized by systemic inflammation，weight loss，skeletal muscle and adipose tissue atrophy，and its underlying mechanisms are unclear and available treatment options are limited. Abnormal expression of brown fat-like phenotypes in cancer cells has previously been linked to tumor growth. Therefore，the expression of brown fat-related proteins in malignant tumors may be related to the prognosis of tumors. This article reviews the expression of UCP1，the decoupling mechanism and the relationship between UCP1 and cancer-associated cachexia. |
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