| 王 瑜,俞 乔.浸润性导管型乳腺癌中金属硫蛋白3的表达及意义[J].肿瘤学杂志,2020,26(1):39-42. |
| 浸润性导管型乳腺癌中金属硫蛋白3的表达及意义 |
| Expression of Metallothionein 3 in Invasive Ductal Breast Cancer and Its Significance |
| 投稿时间：2019-04-03 |
| DOI：10.11735/j.issn.1671-170X.2020.01.B009 |
|
 |
| 中文关键词: 浸润性导管型乳腺癌 金属硫蛋白3 预后 |
| 英文关键词:invasive ductal breast cancer metallothionein 3 prognosis |
| 基金项目: |
|
| 摘要点击次数: 1557 |
| 全文下载次数: 475 |
| 中文摘要: |
| 摘 要：［目的］ 探讨金属硫蛋白3（MT-3）在浸润性导管型乳腺癌中的表达，并分析MT-3表达与肿瘤临床病理及预后之间的关系。［方法］ 选取2012年3月至2014年3月在南京江北人民医院和江苏省肿瘤医院接受治疗的浸润性导管型乳腺癌手术标本112例，采用免疫组织化学检测肿瘤组织和癌旁组织中MT-3的表达，并分析MT-3表达与乳腺癌患者临床病理之间相关性；采用Kaplan-Meier法分析MT-3表达与乳腺癌患者预后的关系。［结果］ MT-3蛋白在乳腺癌组织中的阳性表达率（72.3%）高于癌旁组织中的阳性表达率（25.9%）（P<0.05）。MT-3表达与乳腺癌组织的TNM临床分期、组织学分级以及淋巴结转移呈正相关（P<0.05），而与乳腺癌患者的年龄及其肿瘤大小无明显相关性（P＞0.05）。生存分析结果显示，与MT-3低表达乳腺癌患者5年生存率（83.3%）相比，MT-3高表达患者的5年生存率显著性降低（62.8%）（P<0.05）。［结论］ MT-3在浸润性导管型乳腺癌中过表达，并与肿瘤的发生发展密切相关，有望为浸润性导管型乳腺癌的临床诊疗及预后评估提供新的思路。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of metallothionein 3(MT-3) in invasive ductal breast cancer and its clinicopathological significance. ［Methods］ One hundred and twelve surgical specimens of invasive ductal breast cancer were collected in Jiangbei People's Hospital and Jiangsu Tumor Hospital from March 2012 to March 2014. The expression of MT-3 in ductal breast cancer and its paracancerous tissues was detected by immunohistochemistry. The correlation between the expression of MT-3 and the clinicopathological features of ductal breast cancer was analyzed. The Kaplan-Meier curve was used to evaluate the prognosis of patients. ［Results］ The positive expression of MT-3 in ductal breast cancer tissues(72.3%) was significantly higher than that in adjacent tissues(25.9%)(P<0.05). Expression of MT-3 was positively correlated with TNM stage，histological grade and lymph node metastasis of ductal breast cancer(P<0.05)，but had no significant correlation with the age of patients and tumor size(P>0.05). Kaplan-Meier survival analysis showed that，compared with MT-3 low expression patients，the 5-year survival rate in patients with MT-3 high expression was significantly decreased(83.3% vs. 62.8%，P<0.05). ［Conclusion］ MT-3 is overexpressed in invasive ductal breast cancer and is closely related to the progression of ductal breast cancer. It may provide a new marker for clinical diagnosis and prognosis evaluation of invasive ductal breast cancer. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |