| 罗 慧,汪 琪,张大昕.T淋巴细胞在肿瘤免疫中的双重作用及其免疫治疗现状[J].肿瘤学杂志,2019,25(11):936-940. |
| T淋巴细胞在肿瘤免疫中的双重作用及其免疫治疗现状 |
| Dual Roles of T Lymphocytes in Tumor Immunity and Application in Anti-tumor Immunotherapy |
| 投稿时间：2018-11-12 |
| DOI：10.11735/j.issn.1671-170X.2019.11.B002 |
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| 中文关键词: 免疫治疗 T淋巴细胞亚群 CD4+T细胞 CD8+T细胞 记忆性T细胞 Treg细胞 |
| 英文关键词:immunotherapy T lymphocyte subsets CD4+ T cells CD8+ T cells memory T cells regulatory T-lymphocytes |
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| 摘要点击次数: 1800 |
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| 中文摘要: |
| 摘 要：肿瘤免疫治疗作为一种新的手段取得了备受瞩目的临床疗效，在晚期肿瘤中甚至可以达到临床治愈。T细胞亚群作为机体细胞免疫功能的重要组成部分，在抗肿瘤免疫及肿瘤免疫逃避中均发挥着十分重要的作用。全文就T细胞亚群的生物学特性、在肿瘤免疫激活及肿瘤免疫逃避中的作用和机制及相关肿瘤免疫治疗研究进展作一综述。 |
| 英文摘要: |
| Abstract：Compared with radiotherapy and chemotherapy，anti-tumor immunotherapy as a new modality of cancer treatment has achieved remarkable clinical efficacy，even reaching clinically cure for advanced tumors. As important parts of the cellular immunity T lymphocyte subsets play dual roles in anti-tumor immunity as well as in tumor immune escape. In this article，the biological characteristics of T lymphocyte subsets，its mechanism in tumor immune activation and tumor immune escape，and related research progress in anti-tumor immunotherapy are reviewed. |
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