毛东锋,毛军峰,吴 涛.伊布替尼治疗套细胞淋巴瘤临床研究进展[J].肿瘤学杂志,2019,25(10):916-919. |
伊布替尼治疗套细胞淋巴瘤临床研究进展 |
Progress of Ibrutinib in Treatment of Mantle Cell Lymphoma |
投稿时间:2018-03-15 |
DOI:10.11735/j.issn.1671-170X.2019.10.B013 |
|
|
中文关键词: 伊布替尼 套细胞淋巴瘤 BTK抑制剂 |
英文关键词:Ibrutini mantle cell lymphoma Bruton′s tyrosine kinase inhibitors |
基金项目:甘肃省自然科学基金资助项目(145RJZA151) |
|
摘要点击次数: 1542 |
全文下载次数: 414 |
中文摘要: |
摘 要:套细胞淋巴瘤是一种少见的B细胞非霍奇金淋巴瘤类型,兼有惰性淋巴瘤和侵袭性淋巴瘤的临床病理特点,治疗上以全身化疗及造血干细胞移植为主。伊布替尼是全球第一个上市的布鲁顿氏酪氨酸激酶(Bruton′s tyrosine kinase,BTK)抑制剂,主要通过抑制BTK信号通路,来达到细胞增殖、凋亡及细胞运动的调节。全文就伊布替尼治疗套细胞淋巴瘤临床研究进展作一分析。 |
英文摘要: |
Abstract:Mantle cell lymphoma is a rare type of non-Hodgkin's B-cell lymphoma with clinicopathologic features of both inert and invasive lymphoma. The systemic chemotherapy and hematopoietic stem cell transplantation are the major treatments currently. Ibrutini is the first Bruton's tyrosine kinase(BTK) signaling pathway inhibitor,to achieve the regulation of cell proliferation,apoptosis and migration. The research progress of Ibrutinib in the treatment of mantle cell lymphoma is reviewed in this article. |
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |