| 赵东霞,王丽芳,卢 安.HMGB1在消化系统恶性肿瘤中的研究进展[J].肿瘤学杂志,2019,25(10):910-915. |
| HMGB1在消化系统恶性肿瘤中的研究进展 |
| Research Progress of HMGB1 in Digestive System Malignant Tumor |
| 投稿时间：2018-03-21 |
| DOI：10.11735/j.issn.1671-170X.2019.10.B012 |
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| 中文关键词: HMGB1 消化系统 恶性肿瘤 |
| 英文关键词:HMGB1 digestive system malignant tumor |
| 基金项目: |
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| 中文摘要: |
| 摘 要：消化系统恶性肿瘤在我国恶性肿瘤中较常见，有较高的发病率和死亡率，其早期诊断率低，预后较差。高迁移率族蛋白（HMGB1）是一种非组蛋白染色体结合蛋白，主要存在于细胞核中。近年来研究显示，消化系统肿瘤如肝癌、胃癌、结直肠癌、胰腺癌、食管癌等恶性肿瘤中HMGB1过量表达。当外界环境发生改变时，HMGB1可以主动或被动释放至细胞外，引起下游信号通路的激活，促使肿瘤细胞发生转移、浸润。HMGB1有望成为消化系统恶性肿瘤治疗的新靶点。全文就HMGB1在消化系统恶性肿瘤中的研究进展作一综述。 |
| 英文摘要: |
| Abstract：High mobility group protein box 1(HMGB1) is a non-histone chromosome binding protein，mainly located in the nucleus. In recent years，it has been shown that there is an overexpression of HMGB1 in malignant tumors including liver cancer，stomach cancer，colorectal cancer，pancreatic cancer and esophageal cancer. To respond the external environment changes，HMGB1 can be released from the cells actively or passively，activating the downstream signaling pathway，inducing tumor metastasis and invasion. HMGB1 may become a novel target for cancer therapy. This article reviews the progress of HMGB1 in digestive system malignancies and its potential application. |
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