| 曲日初,马金玉,姚 健.血清微小RNA-451对食管癌放化疗效果评估价值[J].肿瘤学杂志,2019,25(10):896-899. |
| 血清微小RNA-451对食管癌放化疗效果评估价值 |
| Value of Serum Micro RNA-451 in Efficacy Evaluation for Patients with Esophageal Cancer Undergoing Radiochemotherapy |
| 投稿时间：2018-05-15 |
| DOI：10.11735/j.issn.1671-170X.2019.10.B009 |
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| 中文关键词: 食管肿瘤 微小RNA-451 诊断 疗效 |
| 英文关键词:esophageal cancer micro RNA-451 diagnosis effect |
| 基金项目:吉林省卫生厅资助项目（2017Q005） |
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| 摘要点击次数: 1214 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨血清微小RNA-451对食管癌的诊断及放化疗效果评估价值。［方法］ 选择食管癌患者60例（病例组）及同时间段内进行健康体检者60名（对照组），分析血清微小RNA-451与食管癌临床病理特征的相关性及对放化疗效果的评估价值。［结果］ 治疗前病例组患者血清微小RNA-451表达水平高于对照组（t=11.674，P<0.001）。有淋巴转移患者的血清微小RNA-451表达水平高于无淋巴转移者（t=-5.378，P<0.001），临床分期高的患者血清微小RNA-451表达水平高于临床分期低的患者（t=-5.740，P<0.001）。经过治疗后，所有患者的血清微小RNA-451表达水平均降低，其中完全缓解、部分缓解、稳定组患者与治疗前相比，差异均有统计学意义（t=5.297，6.610，3.204；P均<0.05），而进展组与治疗前相比，差异无统计学意义（t=0.725，P=0.489），患者的治疗效果与血清微小RNA-451表达水平下降的幅度之间呈现正相关（r=0.729，P<0.05）。［结论］ 血清微小RNA-451可进行食管癌患者治疗效果的评估。 |
| 英文摘要: |
| Abstract：［Objective］ To assess the application of serum micro RNA-451 in diagnosis and efficacy evaluation for patients with esophageal cancer undergoing radiochemotherapy. ［Methods］ Sixty patients with esophageal cancer undergoing radiochemotherapy were and 60 healthy subjects (control group) were recruited in the study. The value of serum miRNA-451 in diagnosis and efficacy evaluation for esophageal cancer patients was analyzed. ［Results］ The expression level of serum miRNA-451 in cancer patients was higher than that in control group before treatment(t=11.674，P<0.05). The expression of miRNA-451 in patients with lymph node metastasis was higher than that in the patients without lymph node metastasis (t=-5.378，P<0.001)，and the miRNA-451 expression in patients with advance clinical stage was higher than that in patients with early stage (t=-5.740，P<0.001). After treatment，the expression levels of miRNA-451 in CR，PR and SD patients were significantly decreased (t=5.297，6.610，3.204，all P<0.05)，while that in PD patients was not significantly changed (t=0.725，P=0.489). There was a positive correlation between the therapeutic effect and the decrease of serum miRNA-451 level (r=0.729，P<0.05). ［Conclusion］ Serum miRNA-451 may be used as a marker for the therapeutic effect of patients. |
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