| 陆 怡,张 波,蔡 鹄.ω-3 PUFAs防治奥沙利铂联合卡培他滨治疗所致周围神经毒性的临床研究[J].肿瘤学杂志,2019,25(9):817-821. |
| ω-3 PUFAs防治奥沙利铂联合卡培他滨治疗所致周围神经毒性的临床研究 |
| Prevention of Peripheral Neurotoxicity Caused by Oxaliplatin and Capecitabine with ω-3 PUFAs in Colon Cancer Patients |
| 投稿时间：2019-06-12 |
| DOI：10.11735/j.issn.1671-170X.2019.09.B011 |
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| 中文关键词: ω-3多不饱和脂肪酸 奥沙利铂 周围神经病变 |
| 英文关键词:ω-3 polyunsaturated fatty acid oxaliplatin peripheral neuropathy |
| 基金项目:浙江省医药卫生平台计划项目(2016DTA001) |
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| 中文摘要: |
| 摘 要：［目的］观察ω-3多不饱和脂肪酸（ω-3 PUFAs）防治结肠癌患者奥沙利铂联合卡培他滨（XELOX）方案化疗所致的周围神经毒性的有效性，为防治化疗所致周围神经毒性提供临床依据。［方法］ 采用随机、双盲、安慰剂对照研究，将符合纳入标准73例接受XELOX方案化疗的结肠癌患者随机分为治疗组（ω-3 PUFAs+化疗）37例和对照组（安慰剂+化疗）36例。各组均以21d为1个疗程，共治疗6个疗程。观察并分析两组患者化疗前后因奥沙利铂所致神经毒性的发生、严重程度及神经传导。［结果］ 治疗组与对照组周围神经毒性发生率分别为35.13%和72.22%（χ2=43.975，P<0.001），两组周围神经病变严重程度也存在显著性差异(χ2=47.768，P<0.001)。在动作及感觉神经传导方面，化疗后治疗组与对照组的腓肠神经的感觉动作电位（a-SAP）分别为(13.91±1.95)μV和（11.08±2.01）μV（P<0.001）。［结论］ ω-3 PUFAs能降低XELOX方案化疗所致的周围神经毒性发生率及严重程度，有望成为治疗奥沙利铂所致神经毒性的潜在药物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the application of ω-3 polyunsaturated fatty acid(ω-3 PUFAs ) in the prevention and treatment of peripheral neurotoxicity caused by chemotherapy with XELOX(oxaliplatin combined with capecitabine) in patients with colon cancer. ［Methods］ In this randomized，double-blind，placebo-controlled clinical trial，73 patients with colon cancer who received XELOX chemotherapy were assigned into two groups，the study group(n=37) was treated with ω-3 PUFAs and chemotherapy and the control group(n=36) was treated with placebo and chemotherapy. Each course of treatment was 21 days，and all patients were treated for 6 courses. The incidence and severity of peripheral neurotoxicity caused by XELOX chemotherapy were compared between two groups，and the conduction of motor and sensory nerves was also observed in two groups. ［Results］ The incidence of peripheral neurotoxicity in the study group and control group were 35.13% and 72.22%(χ2=43.975，P<0.001). There was also a significant difference in the severity of peripheral neuropathy between two groups (χ2=47.768，P<0.001) . The sensory action potentials(a-SAP) of the sural nerves in the study group and the control group after chemotherapy were(13.91±1.95) μV and (11.08±2.01)μV respectively(P<0.001). ［Conclusion］ ω-3 PUFAs can reduce the incidence and severity of peripheral neurotoxicity caused by XELOX chemotherapy significantly，and it is expected to be a potential drug for the treatment of neurotoxi-city caused by oxaliplatin. |
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