| 廉娟雯,许家玲,华 涛.甲状腺转录因子1表达与晚期肺腺癌患者一线化疗疗效的关系[J].肿瘤学杂志,2019,25(8):723-727. |
| 甲状腺转录因子1表达与晚期肺腺癌患者一线化疗疗效的关系 |
| Relationship Between Thyroid Transcription Factor-1(TTF-1) Expression and Efficacy of First-line Chemotherapy in Patients with Advanced-stage Lung Adenocarcinoma |
| 投稿时间：2018-02-12 |
| DOI：10.11735/j.issn.1671-170X.2019.08.B009 |
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| 中文关键词: 肺腺癌 TTF-1表达 预后 生物标志物 |
| 英文关键词:lung adenocarcinoma TTF-1 prognosis biomarke |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺转录因子1（TTF-1）表达与晚期肺腺癌患者一线化疗疗效的关系。［方法］ 选取134例无法手术的Ⅲ～Ⅳ期EGFR及ALK阴性或状态未知的肺腺癌患者。根据免疫组织化学结果分为TTF-1表达阳性组和阴性组，探讨TTF-1表达与患者一线化疗疗效的关系。［结果］ 134例患者中，TTF-1阳性表达93例（69.4%），阴性表达41例（30.6%）。TTF-1阳性患者一线化疗的客观缓解率（ORR）及疾病控制率（DCR）均高于TTF-1阴性者（33.3% vs 17.1%；86.0% vs 63.4%，P均<0.05）。124 例患者可评价PFS，TTF-1阳性组患者PFS 较TTF-1阴性组延长（6.65 个月 vs 5.00 个月，P<0.001）。TTF-1阳性患者1年生存率高于阴性患者（88.2% vs 52.5%，P<0.001）。Cox多因素分析显示，TTF-1表达与PFS相关（HR=0.815，95%CI：0.596～0.982，P=0.004）。［结论］ TTF-1表达与不可手术晚期肺腺癌患者一线化疗的PFS相关，可作为晚期患者一线化疗的疗效预测指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between thyroid transcription factor-1(TTF-1) expression and the efficacy of first-line chemotherapy in patients with advanced-stage lung adenocarcinoma. ［Methods］ One hundred and thirty four patients with unresectable stage Ⅲ～Ⅳ lung adenocarcinoma and EGFR，ALK negative or unknown were enrolled in the study. According to immunohistochemistry results patients were divided into TTF-1 positive and negative groups. The relationship between TTF-1 expression and the efficacy of first-line chemotherapy was analyzed. ［Results］ In 134 patients，93(69.4%) were positive for TTF-1 and 41(30.6%) were TTF-1 negative. The objective remission rate(ORR) and disease control rate(DCR) in TTF-1-positive patients were significantly higher than those in TTF-1 negative patients(33.3% vs 17.1%，86.0% vs 63.4%，both P<0.05). Progress free survival(PFS) was evaluated in 124 patients，the PFS in TTF-1 positive group was longer than that in TTF-1 negative group(6.65 months vs 5.00 months，P<0.001). The 1-year survival of TTF-1 positive patients was higher than that of negative patients(88.2% vs 52.5%，P<0.001). The multivariable Cox proportional hazards model revealed that TTF-1 expression was associated with PFS(HR=0.815，95%CI：0.596～0.982，P=0.004). ［Conclusion］ The expression of TTF-1 is associated with the PFS of patients with advanced lung adenocarcinoma receiving first-line chemotherapy，which can be used as a prognostic indicator for those patients. |
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