程海东,孙佳鑫,莎仁高娃.CUEDC2在胃癌中的表达及其临床意义[J].肿瘤学杂志,2019,25(8):707-711.
CUEDC2在胃癌中的表达及其临床意义
Expression of CUEDC2 in Gastric Cancer and Its Clinical Significance
投稿时间:2019-01-31  
DOI:10.11735/j.issn.1671-170X.2019.08.B006
中文关键词:  胃肿瘤  CUEDC2  淋巴结转移
英文关键词:gastric neoplasms  CUEDC2  lymph node metastasis
基金项目:内蒙古医科大学科技百万工程项目(YKD2017KJBW(LH)002)
作者单位
程海东 内蒙古医科大学附属医院 
孙佳鑫 内蒙古医科大学附属医院临床医学研究中心 
莎仁高娃 内蒙古医科大学基础医学院 
摘要点击次数: 1549
全文下载次数: 415
中文摘要:
      摘 要:[目的] 探讨胃癌中CUEDC2的表达及其意义。[方法] 选取经病理确诊为胃癌并行手术切除后的30例标本,采用免疫组化方法检测CUEDC2的表达,分析其表达与临床病理特征的关系;采用PCR检测CUEDC2 mRNA在胃癌及癌旁组织中的表达;采用Western blot检测CUEDC2蛋白的表达。[结果] 免疫组化法结果显示,CUEDC2在77%(23/30)的胃癌组织中表达阳性。胃癌组CUEDC2 mRNA水平1.06(4.5)高于癌旁组0.49(0.67),差异有统计学意义(P<0.05)。CUEDC2蛋白在胃癌中的表达量1.04(0.59)高于癌旁组织0.78(0.62),差异有统计学意义(P<0.05)。CUEDC2表达水平与患者性别、年龄、肿瘤大小、分化程度、肿瘤位置均无关,与淋巴结转移、TNM分期有关(P<0.05)。 [结论] CUEDC2在胃癌组织中高表达,有可能成为胃癌诊断及预后判断的标志物。
英文摘要:
      Abstract:[Objective] To investigate the expression of CUEDC2 in gastric cancer and its clinical significance. [Methods] The expression of CUEDC2 protein was detected by immunohistochemistryand Western blot,the expression of CUEDC2 mRNA was detected with RT-PCR in cancer and adjacent gastric tissue samples from 30 patients with gastric cancerand its correlationwithclinicopathological factors was analyzed. [Results] Immunohistochemical results showed that CUEDC2 was positive in 77%(23/30) of gastric cancer tissues.The level of CUEDC2 mRNA in gastric cancer group was 1.06(4.50),which was higher than that in adjacent tissues 0.49(0.67) (P<0.05). The expression of CUEDC2 protein in gastric cancer[1.04(0.59)] was higher than that in adjacent tissues[0.78(0.62)](P<0.05). The expression of CUEDC2 was not correlated to gender,age,tumor size,differentiation and tumor location,but closely correlated with lymph node metastasis and TNM stage(P<0.05).[Conclusion] CUEDC2 is overexpression in gastric cancer,it may be a marker for the diagnosis and prognosis of gastric cancer.
在线阅读   查看全文  查看/发表评论  下载PDF阅读器