| 程海东,孙佳鑫,莎仁高娃.CUEDC2在胃癌中的表达及其临床意义[J].肿瘤学杂志,2019,25(8):707-711. |
| CUEDC2在胃癌中的表达及其临床意义 |
| Expression of CUEDC2 in Gastric Cancer and Its Clinical Significance |
| 投稿时间：2019-01-31 |
| DOI：10.11735/j.issn.1671-170X.2019.08.B006 |
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| 中文关键词: 胃肿瘤 CUEDC2 淋巴结转移 |
| 英文关键词:gastric neoplasms CUEDC2 lymph node metastasis |
| 基金项目:内蒙古医科大学科技百万工程项目（YKD2017KJBW(LH)002） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胃癌中CUEDC2的表达及其意义。［方法］ 选取经病理确诊为胃癌并行手术切除后的30例标本，采用免疫组化方法检测CUEDC2的表达，分析其表达与临床病理特征的关系；采用PCR检测CUEDC2 mRNA在胃癌及癌旁组织中的表达；采用Western blot检测CUEDC2蛋白的表达。［结果］ 免疫组化法结果显示，CUEDC2在77%(23/30)的胃癌组织中表达阳性。胃癌组CUEDC2 mRNA水平1.06（4.5）高于癌旁组0.49（0.67），差异有统计学意义(P<0.05)。CUEDC2蛋白在胃癌中的表达量1.04（0.59）高于癌旁组织0.78（0.62），差异有统计学意义(P<0.05)。CUEDC2表达水平与患者性别、年龄、肿瘤大小、分化程度、肿瘤位置均无关，与淋巴结转移、TNM分期有关（P<0.05）。 ［结论］ CUEDC2在胃癌组织中高表达，有可能成为胃癌诊断及预后判断的标志物。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the expression of CUEDC2 in gastric cancer and its clinical significance. ［Methods］ The expression of CUEDC2 protein was detected by immunohistochemistryand Western blot，the expression of CUEDC2 mRNA was detected with RT-PCR in cancer and adjacent gastric tissue samples from 30 patients with gastric cancerand its correlationwithclinicopathological factors was analyzed. ［Results］ Immunohistochemical results showed that CUEDC2 was positive in 77%(23/30) of gastric cancer tissues.The level of CUEDC2 mRNA in gastric cancer group was 1.06(4.50)，which was higher than that in adjacent tissues 0.49(0.67) (P<0.05). The expression of CUEDC2 protein in gastric cancer［1.04(0.59)］ was higher than that in adjacent tissues［0.78(0.62)］(P<0.05). The expression of CUEDC2 was not correlated to gender，age，tumor size，differentiation and tumor location，but closely correlated with lymph node metastasis and TNM stage(P<0.05).［Conclusion］ CUEDC2 is overexpression in gastric cancer，it may be a marker for the diagnosis and prognosis of gastric cancer. |
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