| 王 尧,巴宏军,文习之.术前血小板水平与可切除肢端黑色素瘤预后相关性[J].肿瘤学杂志,2019,25(7):646-649. |
| 术前血小板水平与可切除肢端黑色素瘤预后相关性 |
| Relationship Between Preoperative Platelet Level and Prognosis in Patients with Resectable Acral Melanoma |
| 投稿时间：2018-11-21 |
| DOI：10.11735/j.issn.1671-170X.2019.07.B012 |
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| 中文关键词: 肢端黑色素瘤 血小板 预后 炎症 |
| 英文关键词:acral melanoma platelet prognosis inflammation |
| 基金项目:国家自然科学基金（81802723） |
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| 摘要点击次数: 1651 |
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| 中文摘要: |
| 摘 要：［目的］ 分析术前外周血中淋巴细胞、中性粒细胞、血小板等指标与可切除的肢端黑色素瘤患者预后的关系。［方法］ 回顾性分析2005年1月至2015年1月在中山大学肿瘤医院接受根治性手术切除的223例Ⅰ~Ⅲ期肢端黑色素瘤患者的临床病理特征及术前血常规各项指标。应用Cox比例风险回归模型进行生存分析；采用Kaplan-Meier法绘制生存曲线并对组间差异进行Log-rank检验。［结果］ 单因素分析结果显示年龄、PS评分、溃疡、肿瘤分期、术前LDH及血小板水平是肢端黑色素瘤患者生存的影响因素。多因素分析结果显示溃疡、肿瘤分期、术前LDH及血小板水平是影响患者预后的独立危险因素（P＜0.05）。在Ⅱ期（P=0.006）和Ⅲ期（P=0.028）患者中，不同术前血小板水平者生存率均具有统计学差异。［结论］溃疡、肿瘤分期、术前LDH和血小板水平是可切除的肢端黑色素瘤患者的独立危险因素，术前常规评估血小板水平有助于临床医师判断患者预后并进行个体化治疗。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the relationship between preoperative blood indicators and prognosis of patients with resectable acral melanoma. ［Methods］ The clinicopathological characteristics and preoperative blood routine parameters of 223 patients with stage Ⅰ~Ⅲ acral melanoma who underwent radical resection at the Sun Yat-sen University Cancer Center from January 2005 to January 2015 were retrospectively analyzed. Kaplan-Meier curves were plotted to estimate overall survival， univariate and multivariate Cox regression was performed to analyze the risk factors of prognosis，and Log-rank test was performed for differences between groups. ［Results］ Univariate analysis showed that age，PS score，ulcer，tumor stage，preoperative LDH and platelet level were associated with poor overall survival. Multivariate analysis showed that ulcer，tumor stage，preoperative LDH and platelet level were independent risk factors of poor survival in patients with acral melanoma(P<0.05). Subgroup analysis showed that the survival rates were significantly different in stage Ⅱ(P=0.006) and stage Ⅲ(P=0.028) patients with different platelet levels. ［Conclusion］ Ulcer，tumor stage，preoperative LDH and platelet level are independent prognostic factors for patients with resectable acral melanoma. Preoperative assessment of platelet level may be helpful for clinicians to assess prognosis and to chose individualized treatment. |
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