| 金 菊,程 晔,乔恩奇.乳腺分泌性癌15例临床病理特征及预后分析[J].肿瘤学杂志,2019,25(7):637-640. |
| 乳腺分泌性癌15例临床病理特征及预后分析 |
| Clinicopathologic Feature and Prognostic Analysis of 15 Cases with Secretory Breast Carcinoma |
| 投稿时间：2018-08-25 |
| DOI：10.11735/j.issn.1671-170X.2019.07.B010 |
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| 中文关键词: 乳腺肿瘤 分泌性癌 临床病理特征 免疫组织化学 预后 |
| 英文关键词:breast neoplasms secretory carcinoma clinicopathologic feature immunohistochemistry prognosis |
| 基金项目:浙江省自然科学基金项目（LY17H290001） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨乳腺分泌性癌的临床病理特征、免疫组织化学表达特点及临床预后。［方法］ 分析15例乳腺分泌性癌的临床表现及病理特征；采用PAS、D-PAS及阿辛蓝染色技术进行细胞分泌物染色，免疫组织化学检测ER、PR、c-erbB-2、Ki-67、p53、EGFR 和CK5/6在肿瘤细胞中的表达，并对11例患者进行随访。［结果］ 乳腺分泌性癌平均年龄49岁，女性患者占93.3%。病理形态学主要特点为癌细胞异型性较小，出现微囊性结构，癌细胞能产生大量分泌物等，对PAS/AB及黏液卡红染色呈现阳性反应。20%患者伴有同侧腋窝淋巴结转移。中位随访38.5个月，未发现肿瘤复发转移和死亡病例。［结论］ 乳腺分泌性癌为一种罕见的肿瘤，具有明显的组织病理学特征，预后良好。 |
| 英文摘要: |
| Abstract：［Purpose］ To analyze the clinicopathological features and prognosis of patients with secretory breast carcinoma（SBC)．［Methods］ Clinical data and pathological characteristics of 15 patients with breast secretory carcinoma were collected and analyzed. Special staining of mucin carmine(MC)，periodic acid-Schiff reaction(PAS) with and without diastase pretreatment and Alcian blue(AB)，immunohistochemical staining(ABC method) of ER，PR，c-erbB-2，Ki-67，p53，EGFR and CK5/6 were performed．Eleven patients were followed up after various treatment. ［Results］ The average age of SBC patients was 49 years，and 14 were women(93.3%). The histopathological characteristics were mild atypia in carcinoma cells，prominent microcystic architecture and large amount of secretion in the cytoplasm and cysts positive for PAS/AB and MC staining． Ipsilateral axillary lymph node metastasis was found in 20% of patients. The median follow-up was 38.5 months，and no tumor recurrence，metastasis or death was observed. ［Conclusion］ SBC is a rare tumor with typical histopathological features and a favorable prognosis． |
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