| 高彦君,姚 颐,宋启斌.癌相关成纤维细胞活化机制的研究进展[J].肿瘤学杂志,2019,25(5):453-457. |
| 癌相关成纤维细胞活化机制的研究进展 |
| Research Progress in Activation Mechanism of Cancer-associa-ted Fibroblasts |
| 投稿时间：2018-10-06 |
| DOI：10.11735/j.issn.1671-170X.2019.05.B016 |
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| 中文关键词: 肿瘤发生 肿瘤微环境 癌相关成纤维细胞 活化 |
| 英文关键词:tumor development tumor microenvironment cancer-associated fibroblasts activation |
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| 中文摘要: |
| 摘 要：癌相关成纤维细胞（cancer associated fibroblasts，CAFs）是肿瘤微环境的重要组成部分，具有活性的CAFs已经被证实可促进肿瘤的发生、发展、转移和耐药，成为癌症治疗的重要目标。现已发现细胞因子、炎症、缺氧、活性氧、自噬及放射线等都可以引起CAFs的活化。深入了解CAFs活化的分子机制和病理机制，有利于为恶性肿瘤治疗提供新的思路和靶点。 |
| 英文摘要: |
| Abstract：Cancer-associated fibroblasts(CAFs) are an important component of the tumor microenvironment. The activated CAFs have been shown to promote tumorigenesis，development，metastasis and drug resistance，and become an important target for cancer treatment. It has been found that cytokines，inflammation，hypoxia，reactive oxygen species，autophagy，and radiation all contribute to the activation of CAFs. The understanding of the molecular and pathological mechanism of CAFs activation may provide new ideas for cancer treatment using CAF as a therapeutic target. |
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