| 马苗苗,古丽米拉木·艾热提,杨 杰.淋巴细胞与单核细胞比值对宫颈癌患者预后的影响[J].肿瘤学杂志,2019,25(5):442-445. |
| 淋巴细胞与单核细胞比值对宫颈癌患者预后的影响 |
| Association of Lymphocyte and Mononuclear Cell Ratio with Prognosis of Patients with Cervical Cancer |
| 投稿时间：2018-03-14 |
| DOI：10.11735/j.issn.1671-170X.2019.05.B013 |
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| 中文关键词: 宫颈癌 鳞状细胞癌 淋巴细胞与单核细胞比值 预后 |
| 英文关键词:cervical cancer squamous cell carcinoma lymphocyte and monocyte ratio prognosis |
| 基金项目:新疆少数民族科技人才特殊培养计划（2016D0230） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨外周血中淋巴细胞与单核细胞比值（lymphocyte-to-monocyte ratio，LMR）对宫颈鳞癌患者预后的影响。［方法］ 收集2010~2013年宫颈鳞状细胞癌患者，FIGO分期ⅡB~ⅣA期及卡氏评分≥70分的122例。根据X-tile软件确定治疗前LMR 最佳临界值为 4。 ［结果］ 122 例患者LMR 范围 1.62～8.51，平均值为4.21，中位值为4.13。 高 LMR 组与低 LMR 组患者的肿块大小和淋巴结转移比较差异有统计学意义（P<0.05）。单因素分析显示临床分期、淋巴结转移、LMR水平和治疗方式影响患者总生存期（P<0.05）。Cox 多因素分析结果显示，LMR水平影响患者预后（HR＝0.532，95%CI：0.132~0.942，P=0.039）。［结论］ 宫颈鳞癌患者外周血中 LMR 可作为宫颈癌患者预后的预测指标。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the association of lymphocyte-to-monocyte ratio(LMR) in peripheral blood with the prognosis of cervical cancer patients. ［Methods］ From 2010 to 2013，122 cases of cervical squamous cell carcinoma were enrolled in the study. Patients had FIGO stages ⅡB~ⅣA and Karnofsky score≥70. According to the X-tile software，the optimal cutoff value of LMR before treatment was determined as 4. ［Results］ The LMR of 122 patients ranged from 1.62 to 8.51 with an average of 4.21 and a median of 4.13. The tumor size and lymph node metastasis in patients with high LMR and low LMR were statistically significant(P<0.05). Univariate analysis showed that clinical stage，lymph node metastases，LMR levels，and treatment modalities were associated with overall survival of patients(P<0.05). Cox multivariate analysis showed that the level of LMR was an independent predictive factor for the prognosis of patients(HR=0.532，95%CI：0.132~0.942，P=0.039). ［Conclusion］ LMR in peripheral blood can be used as a predictor of prognosis of patients with cervical squamous cell carcinoma. |
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