| 何 瀚,黄 荣,蒋 军.放疗对非小细胞肺癌患者循环肿瘤细胞数目的影响[J].肿瘤学杂志,2019,25(5):402-404. |
| 放疗对非小细胞肺癌患者循环肿瘤细胞数目的影响 |
| Effect of Radiotherapy on Circulating Tumor Cells in Patients with Non-Small Cell Lung Cancer |
| 投稿时间：2019-01-07 |
| DOI：10.11735/j.issn.1671-170X.2019.05.B004 |
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| 中文关键词: 循环肿瘤细胞 非小细胞肺癌 放疗 |
| 英文关键词:circulating tumor cells non-small cell lung cancer radiotherapy |
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| 中文摘要: |
| 摘 要：［目的］ 探讨放疗对非小细胞肺癌（non-small cell lung cancer，NSCLC）患者循环肿瘤细胞（CTCs）的影响。［方法］ 选取42例NSCLC患者为研究对象，比较放疗前后CTCs数目的变化情况，并分析各亚组治疗前后CTCs数目的改变。［结果］ 放疗前CTCs数目与患者性别、年龄、吸烟状况及临床分期的无关。与放疗前比较，放疗后CTCs数目下降明显（P＜0.001）；男性、年龄＞60岁及吸烟患者治疗后CTCs数目下降有统计学意义。［结论］ 放疗可以在不同程度上降低CTCs数目，但不同患者异质性较大，需个体化分析和判断。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the effect of radiotherapy on circulating tumor cells (CTCs) in patients with non-small cell lung cancer (NSCLC). ［Methods］ Forty-two patients with NSCLC were enrolled in the study. The changes in the number of CTCs before and after radiotherapy were compared. ［Results］ The number of CTCs before radiotherapy was not related to gender，age，smoking status and clinical stage of patients. Compared with that before radiotherapy，the number of CTCs decreased significantly after radiotherapy(P<0.001). The stratified analysis showed that the number of CTCs after radiotherapy was significantly associated with concurrent chemotherapy，male sex，smoking，and age >60 years(P<0.05). ［Conclusion］ Radiotherapy can reduce the number of CTCs，which is related to age，gender，smoking status and concurrent chemotherapy of patients. |
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