| 韩志兴,赵玉千,刘庆军.TURBT联合放化疗的三联疗法对局限性肌层[J].肿瘤学杂志,2019,25(4):340-344. |
| TURBT联合放化疗的三联疗法对局限性肌层 |
| The Feasibility of Triple Therapy of TURBT Combined with Chemotherapy and Radiotherapy in Treatment of Localized Muscle Invasive Bladder Cancer |
| 投稿时间：2017-11-24 |
| DOI：10.11735/j.issn.1671-170X.2019.04.B011 |
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| 中文关键词: 膀胱肿瘤 经尿道膀胱肿瘤切除术 放射疗法 药物疗法 |
| 英文关键词:bladder cancer transurethral resection of bladder tumor radiotherapy chemotherapy |
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| 中文摘要: |
| 摘 要：［目的］ 探讨经尿道膀胱肿瘤切除(transurethral resection of bladder tumor，TURBT)联合放疗、化疗的三联疗法治疗局限性肌层浸润性膀胱癌患者的效果及生存情况。［方法］ 回顾性分析2008年3月至2013年9月接受治疗的87例局限性肌层浸润性膀胱癌患者，其中45例实施TURBT手术进行部分膀胱切除，术后实施化疗及放疗(保留组)，42例患者选择实施膀胱切除根治性手术(根治组)，对比两组术前术后的生存质量、3年生存率、复发率及转移率。［结果］ 根治组化疗4.0±1.7次，保留组化疗4.2±1.5次，均行3周的放疗。术前，两组的生存质量相当(P>0.05)，术后1年两组的生存质量均有不同程度提高(P<0.05)，且保留组的生理、心理、独立性和精神支柱评分均高于根治组(P<0.05)，两组社会关系和环境评分差异均无统计学意义(P>0.05)。保留组1、2和3年生存率、3年复发率及3年转移率分别为93.33%、77.10%、62.22%、53.33%和22.22%，根治组分别为97.62%、80.95%、69.05%、40.48%和19.05%，差异均无统计学意义(P>0.05)；保留组和根治组的中位生存时间分别为31.0和33.0个月(P>0.05)。［结论］ TURBT联合放疗化疗的三联疗法治疗局限性肌层浸润性膀胱癌患者手术效果与根治性手术相当，但保留了膀胱功能，提高了患者的生存质量。 |
| 英文摘要: |
| Abstract：［Objective］ To investigate the feasibility of triple therapy of transurethral resection of bladder tumor (TURBT) combined with chemotherapy and radiotherapy in treatment of localized muscle invasive bladder cancer. ［Methods］ From March 2008 to September 2013，87 cases localized muscle invasive bladder cancer were analyzed retrospectively，45 cases as the reserved resection group underwent TURBT surgery for partial bladder resection，postoperative chemotherapy and radiotherapy. 42 cases as the radical resection group accepted implement radical surgery. The survival quality of life before and after operation，survival rate，the recurrence rate and transfer rate of 3 years of the 2 groups were recorded and compared. ［Results］ The chemotherapy times of the reserved resection group and the radical resection group were 4.2±1.5 times and 4.0±1.7 times respectively. In the reserved resection group，all patients underwent radiotherapy were 3 weeks. Before operation，the survival quality of life of the 2 groups had no differences(P>0.05). After operation，the physiological and psychological，independence and spiritual support in the reserved resection group were higher than that of the radical resection group (P<0.05). The survival rate after 1 year，2 years and 3 years，the recurrence rate and the transfer rate of the reserved resection group were 93.33%，77.10%，62.22%，53.33% and 22.22%，in the radical group were 97.62%，80.95%， 69.05%，40.48% and 19.05%，there were no significant differences of the indexes between 2 groups(P>0.05). The median survival time was 31 months and 33 months in the reserved resection group and the radical group(P>0.05). ［Conclusion］ The effect of triple therapy of TURBT combined with chemotherapy and radiotherapy in treatment of localized muscle invasive bladder cancer patients is basic equivalent with radical surgery combined with chemotherapy，but triple therapy has retained bladder function，which has better quality of life. |
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