| 王海莉,巩天晓,周士霞.重组人肿瘤坏死因子α诱导蛋白3基因多态性对食管鳞癌预后的影响[J].肿瘤学杂志,2019,25(4):325-329. |
| 重组人肿瘤坏死因子α诱导蛋白3基因多态性对食管鳞癌预后的影响 |
| Association of TNFAIP3 Gene Polymorphisms with Prognosis of Patients with Esophageal Squamous Cell Carcinoma |
| 投稿时间：2017-12-06 |
| DOI：10.11735/j.issn.1671-170X.2019.04.B008 |
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| 中文关键词: 食管鳞癌 重组人肿瘤坏死因子α诱导蛋白3 多态性 预后 |
| 英文关键词:esophageal squamous carcinoma TNFAIP3 polymorphism prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨重组人肿瘤坏死因子α诱导蛋白3（TNFAIP3）的多态性位点6304 A>G和食管鳞癌预后的相关性。［方法］ 纳入175例接受完全手术切除的食管鳞癌患者。在手术前收集患者的外周血5ml提取基因组DNA，采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)的方法对6304 A>G位点进行基因分型，应用SPSS19.0软件对该位点基因型和基线临床资料进行相关性分析，并用Kaplan-Meier方法进行该位点和预后的生存分析。［结果］ 6304 A>G位点在研究人群的基因分布频率为：AA型133例（76.00%），AG型39例（22.29%），GG型3例（1.71%），最小等位基因频率为0.13，三种基因型分布频率符合哈迪温伯格平衡（P=0.942）。野生型AA型相对于AG/GG型患者者具有明显较晚的肿瘤分期（P<0.001）。AA型和AG/GG型患者的复发比例分别为71.43%和52.38%，差异有统计学意义（P=0.022）。AA型患和AG/GG型患者的中位总生存期（OS）分别为36.2个月和48.5个月，差异有统计学意义（P=0.017）。经多变量Cox模型校正后该位点对患者OS具有独立的影响（OR=0.85，P=0.043）。［结论］ TNFAIP36304G>A多态性位点和食管鳞癌患者总生存期显著相关，G等位基因携带者的预后更好。 |
| 英文摘要: |
| Abstract：［Objective］To investigate the association between TNFAIP3 gene polymorphism and the prognosis of patients with esophageal squamous cell carcinoma(ESCC). ［Methods］ One hundred and seventy five patients with ESCC undergoing radical resection were enrolled. Genomic DNA were extracted from peripheral blood samples before the surgery and genotype of TNFAIP3 gene 6304A>G was analyzed by PCR-RFLP. The survival of patients was examined by Kaplan-Meier method and the association between genotypes of TNFAIP3 gene and prognosis of patients were analyzed by SPSS19.0. ［Results］ The prevalence of TNFAIP3 gene 6304A>G among the study population were as follows：AA genotype in 133 cases(76.00%)，AG genotype in 39 cases(22.29%)，GG genotype in 3 cases(1.71%)，the minor allele frequency of 6304A>G was 0.13. The distribution of three genotypes was in accordance with Hardy-Weinberg Equilibrium(P=0.942). Patients with wild genotype AA showed more advanced tumor stages compared to those with AG/GG genotypes(P<0.001). The relapse rate of patients with AA genotype and AG/GG genotype were 71.43% and 52.38% respectively(P=0.022). The median overall survival(OS) of AA genotype and AG/GG genotype patients were 36.2 months and 48.5 months，respectively(P=0.017). Multivariate Cox regression analysis showed that 6304A>G genotype was an independent factor for OS(OR=0.85，P=0.043). ［Conclusion］ The polymorphism 6304A>G of TNFAIP3 gene is associated with overall survival of patients with ESCC，and the G allele carriers may have a better prognosis. |
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