| 中文关键词: 环状RNA 微小RNA 肿瘤发生 |
| 英文关键词:circular RNA microrna oncogenesis |
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| 中文摘要: |
| 摘 要：环状RNA(circular RNAs，circRNAs)是长链非编码RNAs，与线性RNAs不同，它是共价闭合环路，没有5 ′、3 ′极性和腺苷的尾巴。它们具有种类丰富、进化保守、在细胞质中相对稳定的特性。circRNAs的这些特性带来许多潜在的功能，如作为微小RNA(microRNA，miRNA)的海绵，结合RNA相关蛋白质形成RNA-蛋白质复合物，然后调节基因的转录。重要的是，circRNAs突变或异常表达与各种肿瘤的发生、发展密切相关，可以作为肿瘤的分子标志物或潜在治疗靶点，为肿瘤的早期诊断、疗效评价、预后预测和肿瘤基因治疗提供一个新的靶点。 |
| 英文摘要: |
| Abstract：Circular RNAs(circRNAs)，unlike linear RNAs，are long，non-coding RNAs characterized by covalently closed continuous loop without 5′ to 3′ polarity and polyadenylated tail. The circRNAs are enormously abundant，evolutionally conserved and relatively stable in cytoplasm. These features confer numerous potential functions to circRNAs，such as acting as microRNA(miRNA) sponges，binding to RNA associated proteins to form RNA-protein complexes and then regulating gene transcription. Importantly，mutantion or abnormal expression of circRNAs are closely related to the occurrence and development of various tumors. It may provide a molecular marker or potential target for early diagnosis，efficacy evaluation，prognosis and gene therapy of cancers. |
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