| 马 泰,顾康生.靶向肿瘤微环境的策略治疗胰腺癌研究进展[J].肿瘤学杂志,2019,25(2):152-157. |
| 靶向肿瘤微环境的策略治疗胰腺癌研究进展 |
| Research Progress of Tumor Microenvironment-targeted Strategies in Treatment of Pancreatic Cancer |
| 投稿时间：2017-12-08 |
| DOI：10.11735/j.issn.1671-170X.2019.02.B014 |
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| 中文关键词: 胰腺肿瘤 肿瘤微环境 免疫治疗 肿瘤疫苗 |
| 英文关键词:pancreatic tumor tumor microenvironment immunotherapy tumor vaccine |
| 基金项目:安徽省自然科学基金青年项目(1408085QH151) |
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| 摘要点击次数: 1942 |
| 全文下载次数: 471 |
| 中文摘要: |
| 摘 要：晚期胰腺癌预后较差，传统化疗临床效果甚微，胰腺癌特殊的肿瘤微环境决定了其对化疗不敏感。近年来，以肿瘤微环境为靶点的治疗策略在胰腺癌中做了许多探索，全文拟从缺氧微环境、免疫微环境和炎症微环境的角度综述这一领域的研究进展。 |
| 英文摘要: |
| Abstract：Advanced pancreatic cancer is known as having poor prognosis and insensitive to conventional chemotherapy. The chemo-resistance of pancreatic cancer is attributed to its distinctive microenvironment. Strategies targeting on tumor microenvironment have been intensively studied in pancreatic cancer recent years. This article reviews the research progress in therapeutic strategies targeting on the hypoxic microenvironment，immune microenvironment and inflammation microenvironment of pancreatic cancer. |
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